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Study aim: The effect of topical herbal oil based on lavender, Acorus calamus and Turmeric on Taxanes - induced peripheral neuropathy in cancer patients and control group Design: A controlled, double-blind, randomized, phase 2 clinical trial with parallel group, on 75 patients. The rand function of Excel software was used for randomization. Settings and conduct: The location is the Radio-Oncology department of Mahdieh Hospital The control group received 1 cc of placebo oil three times a day, and the intervention group received 6 cc of herbal oil on the surface of the feet and hands. Drug; glass containers with a dropper of one shape and the name of the product as a code Duration of the intervention is 4 weeks, drug test 24 hours before use Participants/Inclusion and exclusion criteria: A 4-week double-blind randomized clinical trial of 74 volunteer patients, 18-80 years of age, patients with breast, gynecological and urological cancer inTehran Mahdieh Hospital, with peripheral neuropathy, response to treatment, assessment of improvement in the scores of the NPS, the FACT/GOG-Ntx, PNQ scale by a physician Intervention groups: Entry criteria • Having cancer with a pathological answer • undergoing chemotherapy or completed chemotherapy within the last two months • Patients with neuropathy, as determined by a neurologist, due to Taxanes chemotherapy • Having peripheral neuropathy of lower or upper limbs or both • Having at least Grade B neuropathy based on the PNQ questionnaire • Not having Guillain-Barre, diabetes, multiple sclerosis and carpal tunnel syndrome • Age 18 - 80 • Willingness to collaborate on the project • Insensitivity to herbal medicines • Stage 1 to 3 patients • No amputations or no wounds on hands and feet • Not having skin cancer • no concurrent radiotherapy Main outcome variables: Sensory and motor disorders of upper and lower limbs, neuropathic pain, symptoms of neuropathy
IRCTID: IRCT20240306061184N1
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