Study aim: The comparison of the effect of face to face and virtual evidence based self care training on the self-management of patients with MS Design: Clinical trial with control group, parallel groups, without blinding, randomized, study on 129 people, for this purpose, random blocks of 4 will be used based on the severity of the disease to assign patients to two groups. There are 6 different combinations of blocks of 4 and (random sequence). Settings and conduct: The intervention is in two stages, the first stage is qualitative to collect educational content and after that it is approved by a panel of experts, and the second stage is a clinical trial on three intervention groups, in person, virtual and control, and the studied subjects are under the supervision of MS Khorramabad Association. Participants/Inclusion and exclusion criteria: 1- Age above 18 years and less than 60 years. 2- Determining of diagnosis of MS disease by a neurologist (having a medical record and having a membership card of the MS Association), 3- Diagnosis of MS at least two years before entering the study 4- Reading and writing literacy 5- Willingness to participate in the study 6- Lack of cognitive problems and communication difficulties, such as vision and hearing defects. 7- Lack of underlying disease (diabetes, cancer and neurological diseases) and mental illness, 8- Patients should have a similar course in terms of disease activity Intervention groups: The study subjects will receive evidence based self care training intervention in three face to face training groups. The second group, as the virtual training group, will receive evidence-based self-care training virtually, and the third group, the control group, will receive routine treatment. Main outcome variables: Self management, age, gender, level of education, marital status, occupation, body mass index, number of rehospitalisations, medications, comorbidities