Study aim: Determining the effect of self-care education in the form of a podcast on the self-esteem and anxiety of patients with multiple sclerosis will be done. Design: A parallel randomized clinical trial including 72 patients, double blinded Settings and conduct: The self-care training program will be held once a week for 6 weeks. The method of the self-care training program will be available to the participants of the test group under pre-produced podcasts. Immediately and two months after the end of the intervention for the test group, both groups will complete the self-esteem questionnaire and the anxiety questionnaire again. Participants/Inclusion and exclusion criteria: Entry criteria: - Membership in Multiple Sclerosis Association of Iran - Age between 18 and 50 years- Having a smartphone with the ability to install WhatsApp software- At least one year has passed since the diagnosis of MS - Being literate in reading and writing. Exit criteria :- Suffering from severe physical limitations caused by the disease (advanced stages of the disease)- Suffering from severe mental disorders- Experience of participating in educational programs related to self-care Intervention groups: In the test group, the participants will be subjected to the intervention of the self-care program. 6 audio files will be prepared and will be held once a week for 6 weeks. The participants of the control group will receive the same treatments and routine care that they received before participating in the study, and at the end of the study, the intervention of the self-care program will also be shared for the control group .Immediately and two months after the completion of the intervention for the test group, both groups will complete the self-esteem questionnaire and the anxiety questionnaire again. Main outcome variables: Self-esteem and worry of patients with multiple sclerosis