Study aim: Evaluating the Effect of Combined Stress-Management Therapy and Pharmacotherapy Compared to Pharmacotherapy Alone on the Quality of Life of Patients with Chronic Urticaria. Design: Patients who had been referred for treatment of chronic urticaria within a few weeks before the start of the study and who currently had active disease were invited to participate in the study. Patients were divided into two groups, case and control, based on personal preference. In addition to drug therapy, the case group received 8 weeks of psychotherapy. The chronic urticaria questionnaire was completed for both groups before and after the intervention. After that, statistical analysis was performed on the two groups.. Settings and conduct: Two non-blinded groups of 50 patients each, selected from recent visitors to Dr. Pourvali’s clinic who had not responded clinically to previous pharmacotherapy. In the control group, only the treatment stage was escalated, while in the intervention group, in addition to the escalated treatment stage, eight weeks of psychotherapy were provided. Participants/Inclusion and exclusion criteria: Inclusion Criteria: Age over 12 years Absence of severe chronic physical or psychological illnesses Diagnosis of chronic spontaneous urticaria Willingness and consent to participate in the study Exclusion Criteria: Incomplete questionnaire data or failure to attend the scheduled sessions. Intervention groups: Intervention: Patients with chronic urticaria who receive both psychotherapy and pharmacological treatment for chronic urticaria. Control: Patients with chronic urticaria who receive only pharmacological treatment for chronic urticaria Main outcome variables: Quality of life of patients with chronic urticaria