Study aim: To determine the effectiveness of spirituality therapy on meaning in life, quality of life, and hope for life among women with multiple sclerosis in Isfahan. Design: A quasi-experimental, parallel-group study with a pretest-posttest design and a control group will be conducted on 30 participants. Participants will be selected using purposive sampling and non-randomly allocated to an intervention group and a control group, with 15 participants in each group. Settings and conduct: The study will be conducted among women with multiple sclerosis attending medical centers and the MS Society in Isfahan Province. Thirty eligible participants will be recruited through purposive sampling and non-randomly allocated to intervention and control groups. The intervention group will receive eight weekly 90-minute group-based spirituality therapy sessions, while the control group will receive no intervention. Outcomes will be assessed using paper-based or online questionnaires. No blinding will be performed. Participants/Inclusion and exclusion criteria: Inclusion Criteria: Participants aged 20–50 years, with at least a high school diploma, who provide informed consent and have no severe concurrent physical or mental illness. Intervention groups: Intervention Group: Participants will receive eight weekly 90-minute group-based spirituality therapy sessions focusing on spirituality, self-awareness, prayer, hope, spiritual beliefs, relationships, meaning in suffering, and self-transcendence. Control Group: Participants will receive no intervention and continue their usual care. Both groups will complete the same outcome assessments. Main outcome variables: Meaning in Life, Quality of Life, Hope for Life.