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Study aim:
Comparison of propofol TIVA versus isoflurane inhalation on myoclonic movements and hemodynamics in abdominal surgery considering gender
Design:
Randomized double-blind parallel-group trial, 182 patients 1:1 with blocks of four. Anesthesiologist unblinded; patients, assessor, analyst blinded. Control: isoflurane
Settings and conduct:
Imam Khomeini Hospital, Ilam, elective abdominal surgery, myoclonus recorded every 15 minutes by blinded observer
Participants/Inclusion and exclusion criteria:
Inclusion: age 18-65, ASA I/II, elective abdominal surgery, no neurologic disease, no CNS drugs, no allergy, not pregnant. Exclusion: withdrawal, severe complications, new diagnosis, need for method change.
Intervention groups:
Intervention: propofol 100-150 µg/kg/min IV plus fentanyl. Control: isoflurane 0.8-1.2 MAC. Induction identical
Main outcome variables:
Incidence and severity of myoclonus using four-point scale (none, mild, moderate, severe)