Nonalcoholic fatty liver disease (NAFLD) is one of the most common prevalent liver diseases, and associates with obesity, diabetes and insulin resistance (IR). Controversy exists regarding optimal macronutrient without energy restriction and beta – cryptoxanthin on NAFLD. The objective of this work is evaluation of the effect of high protein-weight loss diet combined with beta cryptoxanthin supplement on metabolic factors, serum levels of oxidants, inflammatory and adipocytokins among patients with nonalcoholic fatty liver disease. In this randomized, triple-blind, placebo-controlled clinical trial, ninety-two eligible patients, aged between 18–60 years, of both genders, alcohol consumption <20 g/day, serum ALT levels less than five times of the upper limit (maximum limit of 30 for women and 40 for men), lack of associated diseases and drugs with NAFLD will be randomly assign to 4 groups, label as Calorie restricted- high protein diet plus 6 mg beta cryptoxanthin (CR-HPD + β-CX) group, CR-HPD + placebo, Calorie restricted- normal protein diet plus 6mg beta cryptoxanthin (CR-NPD + β-CX) and CR-NPD + placebo (control group) for 3 months. Serum adiponectin and high sensitive-C-reactive protein (CRP) as primary outcomes will be measured.