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Protocol summary
In this study the therapeutic effects of dopamine and nor-epinephrine on pressure of tidal carbon dioxide (ETCO2) was evaluated in patients with septic shock. This study was undertaken in an educational hospital on 40 patients. Patients enrolled in this study include people over 18 years who suffer from septic shock. Shock criteria means arterial pressure less than 70 mm Hg or systolic pressure less than 100 mm Hg and reduced tissue perfusion symptoms, despite administration of at least 1 liter of crystallized solutions will be considered. Persons under 18 years, who received more than 4 hours vasopressor recent episode of shock, severe heart arrhythmia and those with brain death and traumatic patients, were excluded. Patients were divided into 2 groups and individuals in each group were randomized using random numbers table for in each group. The first group received the drug nor-epinephrine, and second group received dopamine. Data include age, sex, primary systolic blood pressure, 30 minutes and 120 minutes after start of treatment and ET-CO2 primary 30 minutes and 120 minutes after ET-CO2 were measured and recorded. The effects of each of these two drugs in treating the symptoms, hemodynamic shock and increasing the amount of ETCO2 were assessed and compared.
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In this study the therapeutic effects of dopamine and nor-epinephrine on pressure of tidal carbon dioxide (ETCO2) was evaluated in patients with septic shock. This study was undertaken in an educational hospital on 40 patients. Patients enrolled in this study include people over 18 years who suffer from septic shock. Shock criteria means arterial pressure less than 70 mm Hg or systolic pressure less than 100 mm Hg and reduced tissue perfusion symptoms, despite administration of at least 1 liter of crystallized solutions will be considered. Persons under 18 years, who received more than 4 hours vasopressor recent episode of shock, severe heart arrhythmia and those with brain death and traumatic patients, were excluded. Patients were divided into 2 groups and individuals in each group were randomized using random numbers table for in each group. The first group received the drug nor-epinephrine, and second group received dopamine. Data include age, sex, primary systolic blood pressure, 30 minutes and 120 minutes after start of treatment and ET-CO2 primary 30 minutes and 120 minutes after ET-CO2 were measured and recorded. The effects of each of these two drugs in treating the symptoms, hemodynamic shock and increasing the amount of ETCO2 were assessed and compared.
در این مطالعه اثر دو داروی دوپامین و نور اپی نفرین را بر روی فشار دی اکسید کربن بازدمی (ETCO2) در بیماران مبتلا به شوک عفونی بررسی می گردد .این مطالعه ی در یک مرکز اموزشی و درمانی بر روی 40 نفر بیمار دچارشوک انجام خواهد شد. بیمارانی که در این مطالعه وارد می شوند شامل افراد بالای 18 سال دچار شوک می باشند. معیار شوک فشار متوسط شریانی کمتر از 70 میلی متر جیوه یا فشار سیستولیک کمتر از 100میلی متر جیوه همراه باعلائم کاهش پرفیوژن بافتی علی رغم تجویز حداقل 1 لیتر محلول کریستالوئید در نظر گرفته می شود. افراد زیر 18 سال ،کسانیکه بیش از 4 ساعت در اپیزود شوک اخیر وازوپرسور دریافت کردند ، کسانیکه مبتلا به آریتمی شدید قلبی باشند و همچنین بیماران مبتلا به مرگ مغزی وبیماران ترومایی از مطالعه کنار گذاشته می شوند. این افراد به 2گروه تقسیم می شوند و افراد در هر گروه بطو ر تصادفی با استفاده از جدول اعداد تصادفی در هر گروه قرار می گیرند. گروه اول داروی نور اپی نفرین او گروه دوم داروی دوپامین دریافت می کنند.اطلاعات مربوط به سن ،جنس ، فشارخون سیتول در بدو ورود و30 دقیقه و 120 دقیقه بعد شروع درمان و ET-CO2 اولیه و ET-CO2 در دقیقه 30 و 120 دقیقه بعد توسط اندازه گیری و ثبت می شود و سپس اثر هر یک از دو داروی فوق الذکر در درمان شوک بر اساس بهبود علایم همودینامیک و افزایش میزان دی اکسید کربن بازدمی بررسی و با یکدیگر مقایسه می گردد.
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در این مطالعه اثر دو داروی دوپامین و نور اپی نفرین را بر روی فشار دی اکسید کربن بازدمی (ETCO2) در بیماران مبتلا به شوک عفونی بررسی می گردد .این مطالعه ی در یک مرکز اموزشی و درمانی بر روی 40 نفر بیمار دچارشوک انجام خواهد شد. بیمارانی که در این مطالعه وارد می شوند شامل افراد بالای 18 سال دچار شوک می باشند. معیار شوک فشار متوسط شریانی کمتر از 70 میلی متر جیوه یا فشار سیستولیک کمتر از 100میلی متر جیوه همراه باعلائم کاهش پرفیوژن بافتی علی رغم تجویز حداقل 1 لیتر محلول کریستالوئید در نظر گرفته می شود. افراد زیر 18 سال ،کسانیکه بیش از 4 ساعت در اپیزود شوک اخیر وازوپرسور دریافت کردند ، کسانیکه مبتلا به آریتمی شدید قلبی باشند و همچنین بیماران مبتلا به مرگ مغزی وبیماران ترومایی از مطالعه کنار گذاشته می شوند. این افراد به 2گروه تقسیم می شوند و افراد در هر گروه بطو ر تصادفی با استفاده از جدول اعداد تصادفی در هر گروه قرار می گیرند. گروه اول داروی نور اپی نفرین او گروه دوم داروی دوپامین دریافت می کنند.اطلاعات مربوط به سن ،جنس ، فشارخون سیتول در بدو ورود و30 دقیقه و 120 دقیقه بعد شروع درمان و ET-CO2 اولیه و ET-CO2 در دقیقه 30 و 120 دقیقه بعد توسط اندازه گیری و ثبت می شود و سپس اثر هر یک از دو داروی فوق الذکر در درمان شوک بر اساس بهبود علایم همودینامیک و افزایش میزان دی اکسید کربن بازدمی بررسی و با یکدیگر مقایسه می گردد.
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comparing the effect of using norepinephrine or dopamine on ETco2 of patients with infectious shock
comparing the effect of using norepinephrine or dopamine on ETco2 of patients with infectious shock
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مقایسه اثراستفاده از نور اپی نفرین یا دوپامین بر روی ETco2 بیماران با شوک عفونی
مقایسه اثراستفاده از نور اپی نفرین یا دوپامین بر روی ETco2 بیماران با شوک عفونی
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394/5000
The first group received epinephrine light medication and the second group received dopamine. Age, sex, blood pressure at baseline and 30 minutes and 120 minutes after treatment and initial ET-CO2 and ET-CO2 at 30 and 120 minutes, respectively. It is then measured and recorded, and then the effects of each of the two drugs mentioned above in treating shock based on improved hemodynamic symptoms and increased CO2 levels are compared and compared.
394/5000 The first group received epinephrine light medication and the second group received dopamine. Age, sex, blood pressure at baseline and 30 minutes and 120 minutes after treatment and initial ET-CO2 and ET-CO2 at 30 and 120 minutes, respectively. It is then measured and recorded, and then the effects of each of the two drugs mentioned above in treating shock based on improved hemodynamic symptoms and increased CO2 levels are compared and compared.
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گروه اول داروی نور اپی نفرین او گروه دوم داروی دوپامین دریافت می کنند.اطلاعات مربوط به سن ،جنس ، فشارخون سیتول در بدو ورود و30 دقیقه و 120 دقیقه بعد شروع درمان و ET-CO2 اولیه و ET-CO2 در دقیقه 30 و 120 دقیقه بعد توسط اندازه گیری و ثبت می شود و سپس اثر هر یک از دو داروی فوق الذکر در درمان شوک بر اساس بهبود علایم همودینامیک و افزایش میزان دی اکسید کربن بازدمی بررسی و با یکدیگر مقایسه می گردد
گروه اول داروی نور اپی نفرین او گروه دوم داروی دوپامین دریافت می کنند.اطلاعات مربوط به سن ،جنس ، فشارخون سیتول در بدو ورود و30 دقیقه و 120 دقیقه بعد شروع درمان و ET-CO2 اولیه و ET-CO2 در دقیقه 30 و 120 دقیقه بعد توسط اندازه گیری و ثبت می شود و سپس اثر هر یک از دو داروی فوق الذکر در درمان شوک بر اساس بهبود علایم همودینامیک و افزایش میزان دی اکسید کربن بازدمی بررسی و با یکدیگر مقایسه می گردد
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The study will be conducted in Imam Khomeini hospital of sari a training center on 138 patients with depressive disorder.
The drugs were formulated and put in a separate container and then given a separate code for each container. The physician, nurse, and patient were unaware of the type of medication, and the patients were randomized based on simple random
The study will be conducted in Imam Khomeini hospital of sari a training center on 138 patients with depressive disorder. The drugs were formulated and put in a separate container and then given a separate code for each container. The physician, nurse, and patient were unaware of the type of medication, and the patients were randomized based on simple random
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این مطالعه ی در یک مرکز اموزشی و درمانی امام خمینی ساری بر روی 138نفر بیمار دچارشوک انجام خواهد شد.
داروها به یک شکل ظاهری تهیه و در یک ظرف جداگانه قرار داده شد و سپس به هر ظرف یک کد جداگانه داده شد و پزشک و پرستار دارویی و بیمار از نوع دارو اطلاعی نداشتندو نهایتا بیماران براساس جدول اعداد تصافی ساده راندوم سازی شدند
این مطالعه ی در یک مرکز اموزشی و درمانی امام خمینی ساری بر روی 138نفر بیمار دچارشوک انجام خواهد شد. داروها به یک شکل ظاهری تهیه و در یک ظرف جداگانه قرار داده شد و سپس به هر ظرف یک کد جداگانه داده شد و پزشک و پرستار دارویی و بیمار از نوع دارو اطلاعی نداشتندو نهایتا بیماران براساس جدول اعداد تصافی ساده راندوم سازی شدند
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The inclusion criteria comprised patients aged 18 years or older, undergone mechanical ventilation, and required vasopressor (dopamine or norepinephrine) for shock therapy
patients under 18 years of age, with trauma, chronic lung disease, definite brain death, cardiac arrhythmia, referred from other centers, or with more than 2-hour hospitalization in the emergency department were excluded from the study.
The inclusion criteria comprised patients aged 18 years or older, undergone mechanical ventilation, and required vasopressor (dopamine or norepinephrine) for shock therapy patients under 18 years of age, with trauma, chronic lung disease, definite brain death, cardiac arrhythmia, referred from other centers, or with more than 2-hour hospitalization in the emergency department were excluded from the study.
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معیارهای ورود به مطالعه شامل بیماران 18 سال و بالاتر ، تحت تهویه مکانیکی و وازوپرسور مورد نیاز (دوپامین یا نوراپی نفرین) برای درمان شوک است.
بیماران زیر 18 سال ، با تروما ، بیماری مزمن ریه ، مرگ قطعی مغز ، آریتمی قلبی ، مراجعه به مراکز دیگر و یا بیشتر از 2 ساعت بستری در بخش اورژانس از مطالعه خارج شدند.
معیارهای ورود به مطالعه شامل بیماران 18 سال و بالاتر ، تحت تهویه مکانیکی و وازوپرسور مورد نیاز (دوپامین یا نوراپی نفرین) برای درمان شوک است. بیماران زیر 18 سال ، با تروما ، بیماری مزمن ریه ، مرگ قطعی مغز ، آریتمی قلبی ، مراجعه به مراکز دیگر و یا بیشتر از 2 ساعت بستری در بخش اورژانس از مطالعه خارج شدند.
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The first group of epinephrine
The second group is dopamine
The first group of epinephrine The second group is dopamine
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گروه اول داروی اپینفرین
گروه دوم داروی دوپامین
گروه اول داروی اپینفرین گروه دوم داروی دوپامین
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ETco2 Measurement
ETco2 Measurement
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میزان فشار دی اکسید کربن بازدمی
میزان فشار دی اکسید کربن بازدمی
General information
Single blinded
Double blinded
singldoubl
1
1
1
1
1
1
2
3
23
40
138
40138
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Modify the number of study samples
Modify the number of study samples
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اصلاح تعداد نمونه های مطالعه
اصلاح تعداد نمونه های مطالعه
Patients with septic shock conditions
Patients with septic shock conditions
بیماران دارای شرایط شوک سپتیک
بیماران دارای شرایط شوک سپتیک
patients under 18 years
patients more than 75 year
Those who received more than 4 hours vasopressor drugs brain death
Those with severe cardiac arrhythmia
Traumatic patient
Brain death
patients under 18 years patients more than 75 year Those who received more than 4 hours vasopressor drugs brain death Those with severe cardiac arrhythmia Traumatic patient Brain death
افراد زیر 18 سال
افراد بالای 75 سال
کسانیکه بیش از 4 ساعت وازوپرسور دریافت کردند
افراد با آریتمی قلبی شدید
افراد ترومایی
افراد با مرگ مغزی
افراد زیر 18 سال افراد بالای 75 سال کسانیکه بیش از 4 ساعت وازوپرسور دریافت کردند افراد با آریتمی قلبی شدید افراد ترومایی افراد با مرگ مغزی
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Simple randomization
Patients were divided into two groups and randomly assigned to each of the two groups. The drugs in each group were of the same size and shape, each of these numbers was coded and sealed in a seal envelope.
Simple randomization Patients were divided into two groups and randomly assigned to each of the two groups. The drugs in each group were of the same size and shape, each of these numbers was coded and sealed in a seal envelope.
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تصادفی سازی ساده
بیماران به 2 گروه تقسیم شدند و طبق جدول اعداد تصادفی در هر یک از این 2 گروه قرار می گیرند. در هر گروه دارو ها در حجم و شکل یکسان قرار دارند و به هر یک از این اعداد کد داده شد و در یک پاکت مهر موم قرار دارندو پرستار دارویی و پزشک معاج بیمار و بیمار از نوع دارویی که استفاده می شود اطلاعی نداشتند.
تصادفی سازی ساده بیماران به 2 گروه تقسیم شدند و طبق جدول اعداد تصادفی در هر یک از این 2 گروه قرار می گیرند. در هر گروه دارو ها در حجم و شکل یکسان قرار دارند و به هر یک از این اعداد کد داده شد و در یک پاکت مهر موم قرار دارندو پرستار دارویی و پزشک معاج بیمار و بیمار از نوع دارویی که استفاده می شود اطلاعی نداشتند.
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Drugs in a similar container in an opaque bag numbered and the prescribing physician and nurse practitioner were unaware.
Drugs in a similar container in an opaque bag numbered and the prescribing physician and nurse practitioner were unaware.
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داروها در ظرف مشابه در یک پاکت اپاک که شماره گذاری شده و پزشک تجویز کننده و پرستار دارویی وبیمار از ان اطلاعی نداشتند
داروها در ظرف مشابه در یک پاکت اپاک که شماره گذاری شده و پزشک تجویز کننده و پرستار دارویی وبیمار از ان اطلاعی نداشتند
40 case
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40 case
40 بیمار
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40 بیمار
Recruitment centers
#1
Name of recruitment center - English: Vice chancellor for research, Mazandaran University of Medical Sciences
Name of recruitment center - Persian: معاونت پژوهشی دانشگاه علوم پزشکی مازندران
Full name of responsible person - English: Ahmadali Enayati
Full name of responsible person - Persian: احمد علی عنایتی
Street address - English: Vice chancellor for research, Mazandaran University of Medical Sciences, Moallem Square
Street address - Persian: میدان معلم، معاونت پژوهشی دانشگاه علوم پزشکی مازندران
City - English: Sari
City - Persian: ساری
Province:
Country: Iran (Islamic Republic of)
Postal code:
Phone:
Fax:
Email:
Web page address:
Name of recruitment center - English: Vice chancellor for research, Mazandaran University of Medical Sciences
Name of recruitment center - Persian: معاونت پژوهشی دانشگاه علوم پزشکی مازندران
Full name of responsible person - English: Ahmadali Enayati
Full name of responsible person - Persian: احمد علی عنایتی
Street address - English: Vice chancellor for research, Mazandaran University of Medical Sciences, Moallem Square
Street address - Persian: میدان معلم، معاونت پژوهشی دانشگاه علوم پزشکی مازندران
City - English: Sari
City - Persian: ساری
Province: Mazandaran
Country: Iran (Islamic Republic of)
Postal code: 4815724971
Phone: +98 11 3336 1700
Fax:
Email: h.aminiahidshti@mazums.ac.ir
Web page address:
Name of recruitment center - English: Vice chancellor for research, Mazandaran University of Medical Sciences Name of recruitment center - Persian: معاونت پژوهشی دانشگاه علوم پزشکی مازندران Full name of responsible person - English: Ahmadali Enayati Full name of responsible person - Persian: احمد علی عنایتی Street address - English: Vice chancellor for research, Mazandaran University of Medical Sciences, Moallem Square Street address - Persian: میدان معلم، معاونت پژوهشی دانشگاه علوم پزشکی مازندران City - English: Sari City - Persian: ساری Province: Mazandaran Country: Iran (Islamic Republic of) Postal code: 4815724971 Phone: +98 11 3336 1700 Fax: Email: h.aminiahidshti@mazums.ac.ir Web page address:
Sponsors / Funding sources
#1
contact.organization_id:
Name of organization / entity - English: Vice chancellor for researche, Mazandaran University of Medical Siences
Name of organization / entity - Persian: معاونت پژوهشی دانشگاه علوم پزشکی مازندران
Full name of responsible person - English: Ahmadali Enayati
Full name of responsible person - Persian: احمد علی عنایتی
Street address - English: Vice chancellor for researche, Mazandaran University of Medical Siences, Moallem Square
Street address - Persian: میدان معلم، معاونت پژوهشی دانشگاه علوم پزشکی مازندران
City - English: Sari
City - Persian: ساری
Province:
Country: Iran (Islamic Republic of)
Postal code:
Phone:
Fax:
Email:
Web page address:
Name of organization / entity - English:
Name of organization / entity - Persian:
Full name of responsible person - English: Ahmadali Enayati
Full name of responsible person - Persian: احمد علی عنایتی
Street address - English: Vice chancellor for researche, Mazandaran University of Medical Siences, Moallem Square
Street address - Persian: میدان معلم، معاونت پژوهشی دانشگاه علوم پزشکی مازندران
City - English: Sari
City - Persian: ساری
Province: Mazandaran
Country: Iran (Islamic Republic of)
Postal code: 4816633131
Phone: +98 11 3336 1700
Fax:
Email: h.aminiahidashti@mazums.ac.ir
Web page address:
contact.organization_id: Name of organization / entity - English: Vice chancellor for researche, Mazandaran University of Medical Siences Name of organization / entity - Persian: معاونت پژوهشی دانشگاه علوم پزشکی مازندران Full name of responsible person - English: Ahmadali Enayati Full name of responsible person - Persian: احمد علی عنایتی Street address - English: Vice chancellor for researche, Mazandaran University of Medical Siences, Moallem Square Street address - Persian: میدان معلم، معاونت پژوهشی دانشگاه علوم پزشکی مازندران City - English: Sari City - Persian: ساری Province: Mazandaran Country: Iran (Islamic Republic of) Postal code: 4816633131 Phone: +98 11 3336 1700 Fax: Email: h.aminiahidashti@mazums.ac.ir Web page address:
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Public
public
empty
Domestic
domestic
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Academic
academic
Vice chancellor for researche, Mazandaran University of Medical Siences
Sari University of Medical Sciences
Vice chancellor for researche, MazandaranSari University of Medical SiencesSciences
معاونت پژوهشی دانشگاه علوم پزشکی مازندران
دانشگاه علوم پزشکی ساری
معاونت پژوهشی دانشگاه علوم پزشکی مازندرانساری
Person responsible for general inquiries
contact.organization_id:
Name of organization / entity - English: Mazandaran University of Medical Sciences
Name of organization / entity - Persian: دانشگاه علوم پزشکی مازندران
Full name of responsible person - English: Hamed Aminiahidashti
Full name of responsible person - Persian: حامد امینی آهی دشتی
Position - English: Assistant Professor
Position - Persian: استادیار
Latest degree:
Area of specialty/work: 0
Area of specialty/work title - English:
Area of specialty/work title - Persian:
Street address - English: Emergency Department, Imam Khomeini Hospital, Amirmazandarani avenue
Street address - Persian: بلوار امیر مازندرانی, بیمارستان امام خمینی (ره), بخش اورژانس
City - English: Sari
City - Persian: ساری
Province:
Province - English:
Province - Persian:
contact.provinces_available: 1
Country: Iran (Islamic Republic of)
Postal code: 4816633131
Phone: +98 11 3336 1700
Mobile: +98 911 354 0546
Fax:
Email: h.aminiahidashti@mazums.ac.ir
Web page address:
contact.organization_id:
Name of organization / entity - English: Mazandaran University of Medical Sciences
Name of organization / entity - Persian: دانشگاه علوم پزشکی مازندران
Full name of responsible person - English: Hamed Aminiahidashti
Full name of responsible person - Persian: حامد امینی آهی دشتی
Position - English: Assistant Professor
Position - Persian: استادیار
Latest degree: specialist
Area of specialty/work: 57
Area of specialty/work title - English:
Area of specialty/work title - Persian:
Street address - English: Emergency Department, Imam Khomeini Hospital, Amirmazandarani avenue
Street address - Persian: بلوار امیر مازندرانی, بیمارستان امام خمینی (ره), بخش اورژانس
City - English: Sari
City - Persian: ساری
Province: Mazandaran
Province - English:
Province - Persian:
contact.provinces_available: 1
Country: Iran (Islamic Republic of)
Postal code: 4816633131
Phone: +98 11 3336 1700
Mobile: +98 911 354 0546
Fax:
Email: h.aminiahidashti@mazums.ac.ir
Web page address:
contact.organization_id: Name of organization / entity - English: Mazandaran University of Medical Sciences Name of organization / entity - Persian: دانشگاه علوم پزشکی مازندران Full name of responsible person - English: Hamed Aminiahidashti Full name of responsible person - Persian: حامد امینی آهی دشتی Position - English: Assistant Professor Position - Persian: استادیار Latest degree: specialist Area of specialty/work: 057 Area of specialty/work title - English: Area of specialty/work title - Persian: Street address - English: Emergency Department, Imam Khomeini Hospital, Amirmazandarani avenue Street address - Persian: بلوار امیر مازندرانی, بیمارستان امام خمینی (ره), بخش اورژانس City - English: Sari City - Persian: ساری Province: Mazandaran Province - English: Province - Persian: contact.provinces_available: 1 Country: Iran (Islamic Republic of) Postal code: 4816633131 Phone: +98 11 3336 1700 Mobile: +98 911 354 0546 Fax: Email: h.aminiahidashti@mazums.ac.ir Web page address:
Person responsible for scientific inquiries
contact.organization_id:
Name of organization / entity - English: Mazandaran University of Medical Sciences
Name of organization / entity - Persian: دانشگاه علوم پزشکی مازندران
Full name of responsible person - English: Hamed Aminiahidashti
Full name of responsible person - Persian: حامد امینی آهی دشتی
Position - English: Assistant Professor
Position - Persian: استادیار
Latest degree:
Area of specialty/work: 0
Area of specialty/work title - English:
Area of specialty/work title - Persian:
Street address - English: Emergency Department, Imam Khomeini Hospital, Amirmazandarani avenue
Street address - Persian: بلوار امیر مازندرانی, بیمارستان امام خمینی(ره), بخش اورژانس
City - English: Sari
City - Persian: ساری
Province:
Province - English:
Province - Persian:
contact.provinces_available: 1
Country: Iran (Islamic Republic of)
Postal code: 4816633131
Phone: +98 11 3336 1700
Mobile: +98 911 354 0546
Fax:
Email: h.aminiahidashti@mazums.ac.ir
Web page address:
Name of organization / entity - English:
Name of organization / entity - Persian:
Full name of responsible person - English: Hamed Aminiahidashti
Full name of responsible person - Persian: حامد امینی آهی دشتی
Position - English: Assistant Professor
Position - Persian: استادیار
Latest degree: specialist
Area of specialty/work: 57
Area of specialty/work title - English:
Area of specialty/work title - Persian:
Street address - English: Emergency Department, Imam Khomeini Hospital, Amirmazandarani avenue
Street address - Persian: بلوار امیر مازندرانی, بیمارستان امام خمینی(ره), بخش اورژانس
City - English: Sari
City - Persian: ساری
Province: Mazandaran
Province - English:
Province - Persian:
contact.provinces_available: 1
Country: Iran (Islamic Republic of)
Postal code: 4816633131
Phone: +98 11 3336 1700
Mobile: +98 911 354 0546
Fax:
Email: h.aminiahidashti@mazums.ac.ir
Web page address:
contact.organization_id: Name of organization / entity - English: Mazandaran University of Medical Sciences Name of organization / entity - Persian: دانشگاه علوم پزشکی مازندران Full name of responsible person - English: Hamed Aminiahidashti Full name of responsible person - Persian: حامد امینی آهی دشتی Position - English: Assistant Professor Position - Persian: استادیار Latest degree: specialist Area of specialty/work: 057 Area of specialty/work title - English: Area of specialty/work title - Persian: Street address - English: Emergency Department, Imam Khomeini Hospital, Amirmazandarani avenue Street address - Persian: بلوار امیر مازندرانی, بیمارستان امام خمینی(ره), بخش اورژانس City - English: Sari City - Persian: ساری Province: Mazandaran Province - English: Province - Persian: contact.provinces_available: 1 Country: Iran (Islamic Republic of) Postal code: 4816633131 Phone: +98 11 3336 1700 Mobile: +98 911 354 0546 Fax: Email: h.aminiahidashti@mazums.ac.ir Web page address:
Person responsible for updating data
contact.organization_id:
Name of organization / entity - English: Mazandaran University of Medical Sciences
Name of organization / entity - Persian: دانشگاه علوم پزشکی مازندران
Full name of responsible person - English: Hamed Aminiahidashti
Full name of responsible person - Persian: حامد امینی آهی دشتی
Position - English: Assistant Professor
Position - Persian: استاد یار
Latest degree:
Area of specialty/work: 0
Area of specialty/work title - English:
Area of specialty/work title - Persian:
Street address - English: Emergency Department, Imam Khomeini Hospita, Amirmazandarani avenue
Street address - Persian: بلوار امیر مازندرانی, بیمارستان امام خمینی (ره), بخش اورژانس
City - English: Sari
City - Persian: ساری
Province:
Province - English:
Province - Persian:
contact.provinces_available: 1
Country: Iran (Islamic Republic of)
Postal code: 4816633131
Phone: +98 11 3336 1700
Mobile: +98 911 354 0546
Fax:
Email: h.aminiahidashti@mazums.ac.ir
Web page address:
Name of organization / entity - English:
Name of organization / entity - Persian:
Full name of responsible person - English: Hamed Aminiahidashti
Full name of responsible person - Persian: حامد امینی آهی دشتی
Position - English: Assistant Professor
Position - Persian: استاد یار
Latest degree: specialist
Area of specialty/work: 57
Area of specialty/work title - English:
Area of specialty/work title - Persian:
Street address - English: Emergency Department, Imam Khomeini Hospita, Amirmazandarani avenue
Street address - Persian: بلوار امیر مازندرانی, بیمارستان امام خمینی (ره), بخش اورژانس
City - English: Sari
City - Persian: ساری
Province: Mazandaran
Province - English:
Province - Persian:
contact.provinces_available: 1
Country: Iran (Islamic Republic of)
Postal code: 4816633131
Phone: +98 11 3336 1700
Mobile: +98 11 3336 1700
Fax:
Email: h.aminiahidashti@mazums.ac.ir
Web page address:
contact.organization_id: Name of organization / entity - English: Mazandaran University of Medical Sciences Name of organization / entity - Persian: دانشگاه علوم پزشکی مازندران Full name of responsible person - English: Hamed Aminiahidashti Full name of responsible person - Persian: حامد امینی آهی دشتی Position - English: Assistant Professor Position - Persian: استاد یار Latest degree: specialist Area of specialty/work: 057 Area of specialty/work title - English: Area of specialty/work title - Persian: Street address - English: Emergency Department, Imam Khomeini Hospita, Amirmazandarani avenue Street address - Persian: بلوار امیر مازندرانی, بیمارستان امام خمینی (ره), بخش اورژانس City - English: Sari City - Persian: ساری Province: Mazandaran Province - English: Province - Persian: contact.provinces_available: 1 Country: Iran (Islamic Republic of) Postal code: 4816633131 Phone: +98 11 3336 1700 Mobile: +98 911 354 054611 3336 1700 Fax: Email: h.aminiahidashti@mazums.ac.ir Web page address:
Sharing plan
yes
yes
yes
yes
yes
yes
yes
yes
yes
yes
yes
yes
yes
yes
empty
All potential data is shared after unidentifiable people
All potential data is shared after unidentifiable people
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کل داده ها بالقوه پس از غیر قابل شناسایی کردن افراد قابل اشتراک گذاری است
کل داده ها بالقوه پس از غیر قابل شناسایی کردن افراد قابل اشتراک گذاری است
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It has started in 2016
It has started in 2016
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از سال 1395شروع شده است
از سال 1395شروع شده است
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Academic researchers
Academic researchers
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محققان دانشگاهی
محققان دانشگاهی
empty
All data analysis and actions are coordinated and informed by the project manager
All data analysis and actions are coordinated and informed by the project manager
empty
کلیه آنالیزها و اقدامات بر روی داده ها با هماهنگی و اطلاع مجری طرح است
کلیه آنالیزها و اقدامات بر روی داده ها با هماهنگی و اطلاع مجری طرح است
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Project Officer - Research Deputy of Mazandaran University of Medical Sciences
Project Officer - Research Deputy of Mazandaran University of Medical Sciences
empty
مجری طرح- معاونت پژوهشی دانشگاه علوم پزشکی مازندران
مجری طرح- معاونت پژوهشی دانشگاه علوم پزشکی مازندران
empty
Written Request to Research Deputy of Mazandaran University of Medical Sciences
Written Request to Research Deputy of Mazandaran University of Medical Sciences
empty
درخواست کتبی به معاونت پژوهشی دانشگاه علوم پزشکی مازندران
درخواست کتبی به معاونت پژوهشی دانشگاه علوم پزشکی مازندران
Protocol summary
Study aim
comparing the effect of using norepinephrine or dopamine on ETco2 of patients with infectious shock
Design
394/5000
The first group received epinephrine light medication and the second group received dopamine. Age, sex, blood pressure at baseline and 30 minutes and 120 minutes after treatment and initial ET-CO2 and ET-CO2 at 30 and 120 minutes, respectively. It is then measured and recorded, and then the effects of each of the two drugs mentioned above in treating shock based on improved hemodynamic symptoms and increased CO2 levels are compared and compared.
Settings and conduct
The study will be conducted in Imam Khomeini hospital of sari a training center on 138 patients with depressive disorder.
The drugs were formulated and put in a separate container and then given a separate code for each container. The physician, nurse, and patient were unaware of the type of medication, and the patients were randomized based on simple random
Participants/Inclusion and exclusion criteria
The inclusion criteria comprised patients aged 18 years or older, undergone mechanical ventilation, and required vasopressor (dopamine or norepinephrine) for shock therapy
patients under 18 years of age, with trauma, chronic lung disease, definite brain death, cardiac arrhythmia, referred from other centers, or with more than 2-hour hospitalization in the emergency department were excluded from the study.
Intervention groups
The first group of epinephrine
The second group is dopamine
Main outcome variables
ETco2 Measurement
General information
Reason for update
Modify the number of study samples
Acronym
IRCT registration information
IRCT registration number:IRCT2015101924606N1
Registration date:2016-10-13, 1395/07/22
Registration timing:registered_while_recruiting
Last update:2020-01-28, 1398/11/08
Update count:1
Registration date
2016-10-13, 1395/07/22
Registrant information
Name
Hamed Aminiahidashti
Name of organization / entity
Country
Iran (Islamic Republic of)
Phone
+98 11 3336 1700
Email address
h.aminiahidashti@mazums.ac.ir
Recruitment status
Recruitment complete
Funding source
Vice chancellor for research, Mazandaran University of Medical Sciences
Expected recruitment start date
2016-02-18, 1394/11/29
Expected recruitment end date
2017-02-18, 1395/11/30
Actual recruitment start date
empty
Actual recruitment end date
empty
Trial completion date
empty
Scientific title
Comparison Dopamine and Nor-epinephrine on End tidal carbon dioxide pressure in patients with septic shock
Public title
End tidal carbon dioxide pressure in patients with septic shock
Purpose
Treatment
Inclusion/Exclusion criteria
Inclusion criteria:
Patients with septic shock conditions
Exclusion criteria:
patients under 18 years
patients more than 75 year
Those who received more than 4 hours vasopressor drugs brain death
Those with severe cardiac arrhythmia
Traumatic patient
Brain death
Age
From 18 years old to 75 years old
Gender
Both
Phase
3
Groups that have been masked
Participant
Care provider
Outcome assessor
Sample size
Target sample size:
138
Randomization (investigator's opinion)
Randomized
Randomization description
Simple randomization
Patients were divided into two groups and randomly assigned to each of the two groups. The drugs in each group were of the same size and shape, each of these numbers was coded and sealed in a seal envelope.
Blinding (investigator's opinion)
Double blinded
Blinding description
Drugs in a similar container in an opaque bag numbered and the prescribing physician and nurse practitioner were unaware.
Placebo
Not used
Assignment
Parallel
Other design features
Secondary Ids
empty
Ethics committees
1
Ethics committee
Name of ethics committee
کمیته اخلاق دانشگاه علوم پزشکی مازندران
Street address
Mazandaran University of Medical Sciences, Jooybar treeway, Imam Square
City
Sari
Province
Mazandaran
Postal code
4815724971
Approval date
2016-07-17, 1395/04/27
Ethics committee reference number
IR.MAZUMS.REC.95.1547
Health conditions studied
1
Description of health condition studied
Septic Shock
ICD-10 code
A41.9
ICD-10 code description
Septicaemia, unspecified, Septic Shock
Primary outcomes
1
Description
Blood pressure
Timepoint
Before intervention, 30 minutes after intervention, 120 minutes after intervention
Method of measurement
mmhg, manometer
2
Description
End Tidal Carbon Dioxide Pressure
Timepoint
Before intervention, 30 minutes after intervention, 120 minutes after intervention
Method of measurement
mmhg, capnograph
Secondary outcomes
1
Description
Heart Rate
Timepoint
Before intervention, 30 minutes after intervention, 120 minutes after intervention
Method of measurement
number per minutes
2
Description
Oxygen Saturation
Timepoint
Before intervention, 30 minutes after intervention, 120 minutes after intervention
Method of measurement
Puls oxymeter
3
Description
Carbon Dioxide Pressure
Timepoint
Before intervention, 30 minutes after intervention, 120 minutes after intervention
Method of measurement
Blood gas
4
Description
Oxygen Pressure
Timepoint
Before intervention, 30 minutes after intervention, 120 minutes after intervention
Method of measurement
Blood gas
Intervention groups
1
Description
Amp Neurepinephrine, 0.5 micro gram/kilogram/minutes, For 2 hours
Category
Treatment - Drugs
2
Description
Amp Dopamine, 5microgram/kilogram/minutes, For 2 hours
Category
Treatment - Drugs
Recruitment centers
1
Recruitment center
Name of recruitment center
Vice chancellor for research, Mazandaran University of Medical Sciences
Full name of responsible person
Ahmadali Enayati
Street address
Vice chancellor for research, Mazandaran University of Medical Sciences, Moallem Square
City
Sari
Province
Mazandaran
Postal code
4815724971
Phone
+98 11 3336 1700
Email
h.aminiahidshti@mazums.ac.ir
Sponsors / Funding sources
1
Sponsor
Name of organization / entity
Mazandaran University of Medical Sciences
Full name of responsible person
Ahmadali Enayati
Street address
Vice chancellor for researche, Mazandaran University of Medical Siences, Moallem Square
City
Sari
Province
Mazandaran
Postal code
4816633131
Phone
+98 11 3336 1700
Email
h.aminiahidashti@mazums.ac.ir
Grant name
Grant code / Reference number
Is the source of funding the same sponsor organization/entity?