Clinical trial comparing the homodynamic changes in two methods of complete intravenous and inhalation anesthetics in renal transplant patients with peritoneal catheterization with laparoscopy

Objectives: The aim of the present study is to evaluate the hemodynamic changes in two methods of complete intravenous and inhalation anesthesia in renal transplant patients with peritoneal catheterization with laparoscopy. Design: Randomized clinical trial. Setting and conduct: Seventy patients were randomly assigned into two groups of complete anesthesia and inhalation anesthesia using random block method. In the anesthetic inhalation group, for induction, sodium thiopental 4 mg/kg used. Isoflurane 1-2.1% used for maintenance anesthesia. In the complete intravenous anesthetic group, for induction, Etomidate 3.0 mg/kg is used. For maintenance of anesthesia, Etomidate 100 mg/kg for the first 10 minutes after induction and followed by 20 mg/kg for up to 10 minutes until the end of the surgery used. In both groups, the hemodynamic changes reported at the first visit to the operating room, after the induction, after intubation, before the injection into the abdominal cavity, after the injection of the gas into the abdominal cavity and then in the recovery room. The population studied: Renal patients who are candidates for peritoneal catheterization with a laparoscope. Inclusion criteria: Age between 18 to 80 years; ASA class I and II exclusion criteria: Complications during or after laparoscopic surgery Interventions: The intervention group is anesthetic inhalation and in the control group, a complete intravenous anesthetic is used. Main outcome measures (variables): Hemodynamic changes include systolic and diastolic blood pressure, arterial blood pressure and heart rate.

Tehran University of Medical Sciences