History
# Registration date Revision Id
2 2021-10-12, 1400/07/20 203706
1 2018-08-29, 1397/06/07 57708
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  • Protocol summary

    Criteria for entering the study: Pcos approved by the gynecologist; The lack of any systemic or endocrine and nervous diseases including cardiovascular disease, diabetes type 1 and 2, . Not taking any hormone other than clomiphene; Marriage; Age of 45;15 years Earning the minimum score (1/3 score of the correction version of the quality of life questionnaire related to health of polycystic ovary syndrome), Quality of life questionnaire 12 questions, minimum score 24-12 The lack of male infertility (confirmed by the Spectrum Test;Exit criteria: Clomiphene's arbitrary interruption; Non-cooperation of research unit to continue treatment; The occurrence of psychological problems such as close relatives during the study, which prevent the completion of the intervention process.
    Inclusion criteria Confirmation of pcos by gynecologist; Marriage; Age 45 to 15 years; Achieving minimum score (1/3 score of quality of life correction questionnaire related to polycystic ovary syndrome), Quality of life questionnaire 12 questions, minimum score 12 to 24; Absence of male infertility (confirmed by spermogram test); Exclusion criteria: Suffering from any systemic or endocrine and neurological diseases, including: cardiovascular disease, type 1 and 2 diabetes, use of any hormonal drug except clomiphene, hookah and alcohol and smoking addiction according to the research unit, no infertility Male (confirmed by spermogram test)
    معیارهای ورود به مطالعه تایید pcos توسط متخصص زنان;عدم ابتلا به هرگونه بیماری سیستمیک یا غدد درون‌ریز و اعصاب شامل: بیماری قلبی عروقی، دیابت نوع 1 و 2، ;عدم مصرف هرگونه داروی هورمونی به‌جز کلومیفن ;تأهل ;سن 45تا15 سال ;کسب حداقل نمره (1/3 نمره اصلاح کيفيت زندگی پرسشنامه مربوط به سلامت سندرم تخمدان پلی کيستيک)، پرسشنامه کيفيت زندگی 12 سؤال، حداقل نمره 12تا 24; عدم ناباروری مردان (تایید شده توسط آزمون اسپراتورم) ;معيارهاي خروج از مطالعه:قطع خودسرانه کلومیفن; عدم همکاری واحد پژوهش جهت ادامه درمان;بروز مشکلات روحی روانی مانند فوت نزدیکان در طی مطالعه که مانع از تکمیل فرایند مداخله گردد
    معیارهای ورود به مطالعه تایید pcos توسط متخصص زنان;;تأهل ;سن 45تا15 سال ;کسب حداقل نمره (1/3 نمره اصلاح کيفيت زندگی پرسشنامه مربوط به سلامت سندرم تخمدان پلی کيستيک)، پرسشنامه کيفيت زندگی 12 سؤال، حداقل نمره 12تا 24; عدم وجود ناباروری مردانه (تایید شده توسط آزمون اسپرموگرام) ; معيارهاي خروج از مطالعه:عابتلا به هرگونه بیماری سیستمیک یا غدد درون‌ریز و اعصاب شامل: بیماری قلبی عروقی، دیابت نوع 1 و 2، مصرف هرگونه داروی هورمونی به‌جز کلومیفن ،اعتیاد به قلیان و الکل و سیگار طبق ا ظهار واحد پژوهش،عدم وجود ناباروری مردانه (تایید شده توسط آزمون اسپرموگرام)
  • General information

    Not blinded
    Double blinded
    1
    1
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    96
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    2018-08-12, 1397/05/21
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    2018-10-13, 1397/07/21
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    2018-10-13, 1397/07/21
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    Applying the opinions of respected professors and judges after the intervention and the defense session
    empty
    اعمال نظرات اساتید محترم و دادوران بعد از انجام مداخله و جلسه دفاع
    By the gynecologist, polycystic ovarian syndrome has been confirmed
    Failure to have any systemic or endocrine disruption, including cardiovascular disease, type 1 and type 2 diabetes, neoplastic diseases
    No addiction to hookah, cigarettes, drugs and alcohol
    Not taking any hormone other than clomiphene
    Earning the minimum basic score (1.3 points for the correction version of the quality of life questionnaire related to health of polycystic ovary syndrome), Quality of life questionnaire 12 questions, minimum score 24-12
    The absence of a male factor in male infertility (confirmed by the Spectrum test)
    Having ages 45-15 years
    By the gynecologist, polycystic ovarian syndrome has been confirmed
    Marital status
    Earning the minimum basic score (1.3 points for the correction version of the quality of life questionnaire related to health of polycystic ovary syndrome), Quality of life questionnaire 12 questions, minimum score 24-12
    Absence of male infertility (confirmed by spermogram test)
    Having ages 45-15 years
    توسط متخصص زنان بیماری سندرم تخمدان پلي كيستيک در آن‌ها تائید شده باشد
    عدم ابتلا به هرگونه بیماری سیستمیک یا غدد درون‌ریز و اعصاب شامل: بیماری قلبی عروقی، دیابت نوع 1 و 2، بیماری‌های نئوپلاستیک
    عدم اعتیاد به مصرف قلیان، سیگار، موادمخدر و الکل
    عدم مصرف هرگونه داروی هورمونی به‌جز کلومیفن
    تأهل
    کسب حداقل نمره پایه (3/1 نمره نسخه اصلاحی پرسشنامه کیفیت زندگی مرتبط با سلامت سندرم تخمدان پلی کیستیک(، پرسشنامه کیفیت زندگی 12 سؤالی حداقل نمره 24-12
    عدم وجود عامل ناباروری مردانه (تائید شده توسط آزمایش اسپرتورام)
    داشتن سن 45-15 سال
    توسط متخصص زنان بیماری سندرم تخمدان پلي كيستيک در آن‌ها تائید شده باشد
    تأهل
    کسب حداقل نمره پایه (3/1 نمره نسخه اصلاحی پرسشنامه کیفیت زندگی مرتبط با سلامت سندرم تخمدان پلی کیستیک(، پرسشنامه کیفیت زندگی 12 سؤالی حداقل نمره 24-12
    عدم وجود عامل ناباروری مردانه (تائید شده توسط آزمایش اسپرموگرام)
    داشتن سن 45-15 سال
    Clomiphon's arbitrary cessation
    Uncooperative research unit to continue treatment
    The emergence of psychological problems such as near-death during the study, which prevents the intervention from completing
    Having any systemic or endocrine and neurological disease based on the patient's question including: cardiovascular disease, type 1 and type 2 diabetes, neoplastic diseases including Cushing's syndrome, congenital adrenal hyperplasia and hyperprolactinemia (approved by a specialist)
    Addiction to hookah, cigarettes, drugs and alcohol according to the research unit
    Taking any hormonal medication except clomiphene
    Presence of male infertility (confirmed by spermogram test)
    قطع خودسرانه کلومیفن
    عدم همکاری واحد پژوهش جهت ادامه درمان
    بروز مشکلات روحی روانی مانند فوت نزدیکان در طی مطالعه که مانع از تکمیل فرایند مداخله گردد
    ابتلا به هرگونه بیماری سیستمیک یا غدد درون‌ریز و اعصاب بر اساس پرسش از بیمار شامل: بیماری قلبی عروقی، دیابت نوع 1 و 2، بیماری‌های نئوپلاستیک ازجمله سندرم کوشینگ، هیپرپلازی مادرزادی آدرنال و هیپر پرولاکتینمی (تائید شده توسط پزشک متخصص)
    اعتیاد به مصرف قلیان، سیگار، مواد مخدر و الکل طبق اظهار واحد پژوهش
    مصرف هرگونه داروی هورمونی به‌جز کلومیفن
    وجود عامل ناباروری مردانه (تائید شده توسط آزمایش اسپرموگرام)
    The study will be blind-doubled. In this way, patients will be blinded according to the type of intervention. Patients participating in the study will not know whether the pressure points are real acupressure points or false points. Also statistical analyst about the data of the intervention group (real points of acupressure) and the control group (false points of acupressure) Will not know.
    مطالعه به صورت دوسویه کورسازی خواهد شد.بدین صورت که بیماران نسبت به نوع مداخله کورسازی خواهند شد . بیماران شرکت کننده در طرح، از اینکه نقاط تحت فشار، نقاط واقعی طب فشاری هستند یا نقاط کاذب، اطلاعی نخواهند داشت. همچنین تحلیل گر آماری در مورد داده های گروه مداخله (نقاط واقعی طب فشاری) و گروه کنترل(نقاط کاذب طب فشاری) اطلاعی نخواهد داشت.
  • Intervention groups

    #1
    Intervention group: Intervention in Group A (acupressure points) for three months (equivalent to 12 weeks) twice a week, each session for one hour (every 12 minutes including REN-3, REN-4, IV3 L, SP10, (SP6) will begin with an amount of pressure so that the affected spot becomes anesthetized. The location of acupressure points and false points will be determined by the laser pointing machine.
    Intervention group: Intervention in group A (real points of acupressure) for a month and a half (equivalent to 12 sessions) twice a week, each session for one hour (each point 5 minutes including points REN-3, REN-4, IV3 L, SP10, (SP6) and will start with the amount of pressure to the extent that the pressure point is anesthetized. The location of acupressure points and false points will be determined by a laser point detector.
    گروه مداخله: مداخله در گروه A (نقاط واقعی طب فشاری) به مدت سه ماه (معادل 12 هفته) دو بار در هفته، هر جلسه به مدت یک ساعت (هر نقطه 12 دقیقه شامل نقاط REN-3، REN-4،IV3 L، SP10، (SP6و با میزان فشار در حدی که نقطه تحت‌فشار دچار بی‌حسی گردد، آغاز خواهد گردید. محل نقاط طب فشاری و نقاط کاذب توسط دستگاه نقطه یاب لیزری تعیین خواهد شد.
    گروه مداخله: مداخله در گروه A (نقاط واقعی طب فشاری) به مدت یک ماه و نیم(معادل 12 جلسه) دو بار در هفته، هر جلسه به مدت یک ساعت (هر نقطه ۵دقیقه شامل نقاط REN-3، REN-4،IV3 L، SP10، (SP6و با میزان فشار در حدی که نقطه تحت‌فشار دچار بی‌حسی گردد، آغاز خواهد گردید. محل نقاط طب فشاری و نقاط کاذب توسط دستگاه نقطه یاب لیزری تعیین خواهد شد.
    #2
    Control group: Intervention in group B (acupressure pseudotropic points) for three months (equivalent to 12 weeks) twice a week, each session for one hour (every 12 minutes including REN-3, REN-4, IV3 L, SP10 , SP6) and will begin with an amount of pressure to the point where the affected spot becomes anesthetized. The location of acupressure points and false points will be determined by the laser point finder
    Control group: intervention in group B (false points of acupressure), for a month and a half (equivalent to 12 sessions) twice a week, each session for one hour (each point 5 minutes including points REN-3, REN-4, IV3 L, SP10, SP6) and will start with the amount of pressure to the extent that the pressure point is anesthetized. The location of acupressure points and false points will be determined by a laser point detector
    گروه کنترل: مداخله در گروه ب (نقاط کاذب طب فشاری)، به مدت سه ماه (معادل 12 هفته) دو بار در هفته، هر جلسه به مدت یک ساعت (هر نقطه 12 دقیقه شامل نقاط REN-3، REN-4،IV3 L، SP10، SP6)و با میزان فشار در حدی که نقطه تحت‌فشار دچار بی‌حسی گردد، آغاز خواهد گردید. محل نقاط طب فشاری و نقاط کاذب توسط دستگاه نقطه یاب لیزری تعیین خواهد شد
    گروه کنترل: مداخله در گروه ب (نقاط کاذب طب فشاری)، به مدت یک ماه و نیم(معادل 12 جلسه) دو بار در هفته، هر جلسه به مدت یک ساعت (هر نقطه ۵دقیقه شامل نقاط REN-3، REN-4،IV3 L، SP10، SP6)و با میزان فشار در حدی که نقطه تحت‌فشار دچار بی‌حسی گردد، آغاز خواهد گردید. محل نقاط طب فشاری و نقاط کاذب توسط دستگاه نقطه یاب لیزری تعیین خواهد شد

Protocol summary

Study aim
The effect of acupressure on quality of life in patients with pcos
Design
Clinical trials with control group, with parallel groups, randomized
Settings and conduct
Study Type: Clinical Trial Sample number: 96 people Sample collection site: Women's specialized gynecology clinic located in Yasuj Mofattah Clinic Data gathering tool: Clinical signs checklist, Laboratory biomarkers and correctional version of the quality of life questionnaire related to health of polycystic ovary syndrome, 12 questions of quality of life questionnaire Mode of intervention: Split the samples into acupressure group and acupressure pseudo group Data Measurement: Before intervention, three months after intervention
Participants/Inclusion and exclusion criteria
Inclusion criteria Confirmation of pcos by gynecologist; Marriage; Age 45 to 15 years; Achieving minimum score (1/3 score of quality of life correction questionnaire related to polycystic ovary syndrome), Quality of life questionnaire 12 questions, minimum score 12 to 24; Absence of male infertility (confirmed by spermogram test); Exclusion criteria: Suffering from any systemic or endocrine and neurological diseases, including: cardiovascular disease, type 1 and 2 diabetes, use of any hormonal drug except clomiphene, hookah and alcohol and smoking addiction according to the research unit, no infertility Male (confirmed by spermogram test)
Intervention groups
Group (A): The subject's group of acupressure points with clomiphene Group( B): Group of Acupuncture Pseudo-Pseudoephedrons with Clomiphene
Main outcome variables
Improving the quality of life of patients with polycystic ovary syndrome

General information

Reason for update
Applying the opinions of respected professors and judges after the intervention and the defense session
Acronym
IRCT registration information
IRCT registration number: IRCT20180725040587N1
Registration date: 2018-08-29, 1397/06/07
Registration timing: registered_while_recruiting

Last update: 2021-11-01, 1400/08/10
Update count: 1
Registration date
2018-08-29, 1397/06/07
Registrant information
Name
Marzieh Nekooi Nematollahi
Name of organization / entity
Country
Iran (Islamic Republic of)
Phone
+98 74 3333 7230
Email address
nekooim@yahoo.com
Recruitment status
Recruitment complete
Funding source
Expected recruitment start date
2018-08-12, 1397/05/21
Expected recruitment end date
2018-09-12, 1397/06/21
Actual recruitment start date
2018-08-12, 1397/05/21
Actual recruitment end date
2018-10-13, 1397/07/21
Trial completion date
2018-10-13, 1397/07/21
Scientific title
The effect of acupressure on quality of life in patients with polycystic ovarian syndrome
Public title
The effect of acupressure on quality of life in patients with polycystic ovarian syndrome
Purpose
Supportive
Inclusion/Exclusion criteria
Inclusion criteria:
By the gynecologist, polycystic ovarian syndrome has been confirmed Marital status Earning the minimum basic score (1.3 points for the correction version of the quality of life questionnaire related to health of polycystic ovary syndrome), Quality of life questionnaire 12 questions, minimum score 24-12 Absence of male infertility (confirmed by spermogram test) Having ages 45-15 years
Exclusion criteria:
Having any systemic or endocrine and neurological disease based on the patient's question including: cardiovascular disease, type 1 and type 2 diabetes, neoplastic diseases including Cushing's syndrome, congenital adrenal hyperplasia and hyperprolactinemia (approved by a specialist) Addiction to hookah, cigarettes, drugs and alcohol according to the research unit Taking any hormonal medication except clomiphene Presence of male infertility (confirmed by spermogram test)
Age
From 15 years old to 45 years old
Gender
Female
Phase
N/A
Groups that have been masked
  • Participant
  • Data analyser
Sample size
Target sample size: 96
Actual sample size reached: 96
Randomization (investigator's opinion)
Randomized
Randomization description
Simple randomization using software Sample Randomizer
Blinding (investigator's opinion)
Double blinded
Blinding description
The study will be blind-doubled. In this way, patients will be blinded according to the type of intervention. Patients participating in the study will not know whether the pressure points are real acupressure points or false points. Also statistical analyst about the data of the intervention group (real points of acupressure) and the control group (false points of acupressure) Will not know.
Placebo
Used
Assignment
Parallel
Other design features

Secondary Ids

empty

Ethics committees

1

Ethics committee
Name of ethics committee
Ethics Committee in Yasouj University of Medical Sciences
Street address
Yasuj-Shahid Motahari Blvd.-Yasouj University of Medical Sciences
City
Yasouj
Province
Kohgilouyeh-va-Boyrahmad
Postal code
7591741417
Approval date
2018-07-20, 1397/04/29
Ethics committee reference number
IR.YUMS.REC.1397.035

Health conditions studied

1

Description of health condition studied
Polycystic ovary syndrome
ICD-10 code
E28.2
ICD-10 code description
Polycystic ovarian syndrome

Primary outcomes

1

Description
Quality of Life in Patients with Polycystic Ovary Syndrome
Timepoint
Before the intervention, three months after the intervention
Method of measurement
Modified Polycystic Ovary Syndrome Health-Related Quality Of Life Questionnaire (MPCOSQ) ،Short Form12 (SF-12)

Secondary outcomes

1

Description
Hirsutism
Timepoint
Before intervention, three months after the intervention
Method of measurement
Friedman Galway Scale

2

Description
Acne
Timepoint
Before intervention, three months after the intervention
Method of measurement
Global Acne Grading System (GAGS)

3

Description
Alopecia
Timepoint
Before intervention, three months after the intervention
Method of measurement
Ludwig scale

4

Description
Total Testosterone
Timepoint
Before intervention, three months after the intervention
Method of measurement
NG/L

Intervention groups

1

Description
Intervention group: Intervention in group A (real points of acupressure) for a month and a half (equivalent to 12 sessions) twice a week, each session for one hour (each point 5 minutes including points REN-3, REN-4, IV3 L, SP10, (SP6) and will start with the amount of pressure to the extent that the pressure point is anesthetized. The location of acupressure points and false points will be determined by a laser point detector.
Category
Lifestyle

2

Description
Control group: intervention in group B (false points of acupressure), for a month and a half (equivalent to 12 sessions) twice a week, each session for one hour (each point 5 minutes including points REN-3, REN-4, IV3 L, SP10, SP6) and will start with the amount of pressure to the extent that the pressure point is anesthetized. The location of acupressure points and false points will be determined by a laser point detector
Category
Lifestyle

Recruitment centers

1

Recruitment center
Name of recruitment center
Women's Specialty Clinic located in the martyr Mohfat Clinic affiliated to Yasouj University of Medi
Full name of responsible person
Dr. Bahram Mohammadi
Street address
Golestan No. 10,60 Metro Street
City
Yasouj
Province
Kohgilouyeh-va-Boyrahmad
Postal code
7591741417
Phone
+98 74 1222 3299
Email
nekooim@yahoo.com

Sponsors / Funding sources

1

Sponsor
Name of organization / entity
Yasouj University of Medical Sciences
Full name of responsible person
Dr Hossein Marie ouriad
Street address
Yasuj, Blvd. Motahi, Yasouj University of Medical Sciences
City
Yasouj
Province
Kohgilouyeh-va-Boyrahmad
Postal code
7591741417
Phone
+98 74 3333 7230
Email
nekooim@yahoo.com
Grant name
Grant code / Reference number
Is the source of funding the same sponsor organization/entity?
Yes
Title of funding source
Yasouj University of Medical Sciences
Proportion provided by this source
100
Public or private sector
Public
Domestic or foreign origin
Domestic
Category of foreign source of funding
empty
Country of origin
Type of organization providing the funding
Academic

Person responsible for general inquiries

Contact
Name of organization / entity
Yasouj University of Medical Sciences
Full name of responsible person
Doctor Naza Afrin Hosseini
Position
Assistant professor
Latest degree
Ph.D.
Other areas of specialty/work
Nursery
Street address
Yasouj University of Medical Sciences،School of Nursing and Midwifery Zeinab Yasouj
City
Yasouj
Province
Kohgilouyeh-va-Boyrahmad
Postal code
75919-94799
Phone
+98 74 3323 5140
Email
hosseinichenar@yahoo.com

Person responsible for scientific inquiries

Contact
Name of organization / entity
Yasouj University of Medical Sciences
Full name of responsible person
Dr. Nazafarin Hosseini
Position
Assistant Professor
Latest degree
Ph.D.
Other areas of specialty/work
Nursery
Street address
Yasouj University of Medical Sciences،School of Nursing and Midwifery Zeinab Yasouj
City
Yasouj
Province
Kohgilouyeh-va-Boyrahmad
Postal code
75919-94799
Phone
+98 74 3323 5140
Email
hosseinichenar@yahoo.com

Person responsible for updating data

Contact
Name of organization / entity
Yasouj University of Medical Sciences
Full name of responsible person
Marzieh Nokui Nematollahi
Position
Student
Latest degree
Bachelor
Other areas of specialty/work
Nursery
Street address
Yasouj University of Medical Sciences،School of Nursing and Midwifery Zeinab Yasouj
City
Yasouj
Province
Kohgilouyeh-va-Boyrahmad
Postal code
75919-94799
Phone
+98 74 3323 5140
Email
nekooim@yahoo.com

Sharing plan

Deidentified Individual Participant Data Set (IPD)
Undecided - It is not yet known if there will be a plan to make this available
Study Protocol
Undecided - It is not yet known if there will be a plan to make this available
Statistical Analysis Plan
Undecided - It is not yet known if there will be a plan to make this available
Informed Consent Form
Undecided - It is not yet known if there will be a plan to make this available
Clinical Study Report
Undecided - It is not yet known if there will be a plan to make this available
Analytic Code
Undecided - It is not yet known if there will be a plan to make this available
Data Dictionary
Undecided - It is not yet known if there will be a plan to make this available
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