Red color represents old content. It may be empty showing addition in the new version.
Green color represents new content. It may be empty showing deletion in the new version.
Inline
Side by side
Added new contents,
deleted old contents,contents that are not changed.
New table contents
New table contents
Old table contents
Old table contents
Unchanged contents
Unchanged contents
Added new contents, contents that are not changed.
Deleted old contents, contents that are not changed.
Old table contents
Old table contents
Unchanged contents
Unchanged contents
New table contents
New table contents
Unchanged contents
Unchanged contents
Protocol summary
The purpose of this study to investigate the effect of resistance training on serum levels High Sensitivity-Cardiac Troponin I, N-terminal proBrain Natriuretic Peptid, growth-differentiation factor 15 and The markers of heart damage are in older men.
The purpose of this study to investigate the effect of resistance training on serum levels High Sensitivity-Cardiac Troponin I, N-terminal proBrain Natriuretic Peptid, growth-differentiation factor 15 and The markers of heart damage are in Healthy and diabetic elderly men.
The purpose of this study to investigate the effect of resistance training on serum levels High Sensitivity-Cardiac Troponin I, N-terminal proBrain Natriuretic Peptid, growth-differentiation factor 15 and The markers of heart damage are in olderHealthy and diabetic elderly men.
هدف از مطالعه حاضر آثار تمرین مقاومتی بر سطوح سرمی High Sensitivity-Cardiac Troponin I, N-terminal proBrain Natriuretic Peptid, growth-differentiation factor 15 و مارکرهای آسیب قلبی (creatine kinase-myocardial band, Creatine kinase, Lactate Dehydrogenase) در مردان سالمند می باشد.
هدف از مطالعه حاضر آثار تمرین مقاومتی بر سطوح سرمی High Sensitivity-Cardiac Troponin I, N-terminal proBrain Natriuretic Peptid, growth-differentiation factor 15 و مارکرهای آسیب قلبی (creatine kinase-myocardial band, Creatine kinase, Lactate Dehydrogenase) در مردان سالمند سالم و دیابتی می باشد.
هدف از مطالعه حاضر آثار تمرین مقاومتی بر سطوح سرمی High Sensitivity-Cardiac Troponin I, N-terminal proBrain Natriuretic Peptid, growth-differentiation factor 15 و مارکرهای آسیب قلبی (creatine kinase-myocardial band, Creatine kinase, Lactate Dehydrogenase) در مردان سالمند سالم و دیابتی می باشد.
General information
24
empty
24
empty
In the name of God
Given that the Vice Chancellor for Research and Technology of Guilan University of Medical Sciences sent a comprehensive letter to that center to obtain a clinical trial code, I conducted research and sampling on healthy and diabetic elderly people. Unfortunately, I have encountered a problem in publishing the second article related to the section on diabetic elderly people, and the editor of the journal has requested that the words "healthy and diabetic" be added. In addition, given that it was the first time I was registering the research subject information to obtain a clinical trial code, I had completed some parts incompletely, which is currently being corrected. Please instruct the esteemed clinical trial code registrar to change the subject to the following form so that my problem can be resolved (the words "healthy and diabetic" should be added to the end of the subject): "Effects of resistance training on serum levels of hs-CTnI, NT-proBNP, GDF-15 and cardiac injury markers in healthy and diabetic elderly men"
In the name of God Given that the Vice Chancellor for Research and Technology of Guilan University of Medical Sciences sent a comprehensive letter to that center to obtain a clinical trial code, I conducted research and sampling on healthy and diabetic elderly people. Unfortunately, I have encountered a problem in publishing the second article related to the section on diabetic elderly people, and the editor of the journal has requested that the words "healthy and diabetic" be added. In addition, given that it was the first time I was registering the research subject information to obtain a clinical trial code, I had completed some parts incompletely, which is currently being corrected. Please instruct the esteemed clinical trial code registrar to change the subject to the following form so that my problem can be resolved (the words "healthy and diabetic" should be added to the end of the subject): "Effects of resistance training on serum levels of hs-CTnI, NT-proBNP, GDF-15 and cardiac injury markers in healthy and diabetic elderly men"
empty
به نام خدا
با توجه به اینکه معاونت تحقیقات و فناوری دانشگاه علوم پزشکی گیلان در نامه ای که برای اخذ کُد کارآزمایی بالینی به آن مرکز ارسال نموده بودند، به شکل جامع بود لذا بنده بر روی سالمندان سالم و دیابتی تحقیق و نمونه گیری انجام دادم که متأسفانه جهت چاپ مقاله دوم مربوط به بخش سالمندان دیابتی، بنده به مشکل برخورد نموده ام و مدیر نشریه درخواست اضافه نمودن واژه های "سالم و دیابتی" را دارند. در ضمن با توجه به اینکه اولین بار بود اطلاعات موضوع تحقیق را جهت اخذ کد کارآزمایی بالینی ثبت می نمودم برخی قسمت ها را نیز به شکل ناقص تکمیل نموده بودم که فی الحال اصلاح می گردد. خواهشمند است دستور فرمائید متصدی محترم ثبت کد کارآزمایی بالینی، موضوع را به شکل ذیر تغییر دهند تا مشکل بنده برطرف شود (واژه های "سالم و دیابتی" به انتهای موضوع اضافه گردد):
"آثار تمرین مقاومتی بر سطوح سرمی hs-CTnI, NT-proBNP, GDF-15 و مارکرهای آسیب قلبی در مردان سالمند سالم و دیابتی"
به نام خدا با توجه به اینکه معاونت تحقیقات و فناوری دانشگاه علوم پزشکی گیلان در نامه ای که برای اخذ کُد کارآزمایی بالینی به آن مرکز ارسال نموده بودند، به شکل جامع بود لذا بنده بر روی سالمندان سالم و دیابتی تحقیق و نمونه گیری انجام دادم که متأسفانه جهت چاپ مقاله دوم مربوط به بخش سالمندان دیابتی، بنده به مشکل برخورد نموده ام و مدیر نشریه درخواست اضافه نمودن واژه های "سالم و دیابتی" را دارند. در ضمن با توجه به اینکه اولین بار بود اطلاعات موضوع تحقیق را جهت اخذ کد کارآزمایی بالینی ثبت می نمودم برخی قسمت ها را نیز به شکل ناقص تکمیل نموده بودم که فی الحال اصلاح می گردد. خواهشمند است دستور فرمائید متصدی محترم ثبت کد کارآزمایی بالینی، موضوع را به شکل ذیر تغییر دهند تا مشکل بنده برطرف شود (واژه های "سالم و دیابتی" به انتهای موضوع اضافه گردد): "آثار تمرین مقاومتی بر سطوح سرمی hs-CTnI, NT-proBNP, GDF-15 و مارکرهای آسیب قلبی در مردان سالمند سالم و دیابتی"
The effects of resistance training on serum levels of hs-CTnI, NT-proBNP, GDF-15, and cardiac damage markers in elderly men
The effects of resistance training on serum levels of hs-CTnI, NT-proBNP, GDF-15, and cardiac damage markers in healthy and diabetic elderly men
The effects of resistance training on serum levels of hs-CTnI, NT-proBNP, GDF-15, and cardiac damage markers in healthy and diabetic elderly men
آثار تمرین مقاومتی بر سطوح سرمی hs-CTnI, NT-proBNP, GDF-15 و مارکرهای آسیب قلبی در مردان سالمند
آثار تمرین مقاومتی بر سطوح سرمی hs-CTnI, NT-proBNP, GDF-15 و مارکرهای آسیب قلبی در مردان سالمند سالم و دیابتی
آثار تمرین مقاومتی بر سطوح سرمی hs-CTnI, NT-proBNP, GDF-15 و مارکرهای آسیب قلبی در مردان سالمند سالم و دیابتی
Have cardiovascular disease
Have diabetes and hypertension
Have diabetes and hypertension
Take regular medication
Have regular exercise in the last 1 year
Have cardiovascular disease
Use tobacco and alcohol
Have been regularly involved in sports activities in the last 1 year
Have cardiovascular disease Have diabetesUse tobacco and hypertensionalcohol Have diabetes and hypertension Take regular medication Have regular exercisebeen regularly involved in sports activities in the last 1 year
بیماری های قلبی عروقی داشته باشند
بیماری دیابت و فشار خون داشته باشند
دخانیات و الکل مصرف کنند
بطور منظم دارو مصرف کنند
به صورت منظم در 1 سال اخیر فعالیت ورزشی داشته باشند
بیماری های قلبی عروقی داشته باشند
دخانیات و الکل مصرف کنند
به صورت منظم در 1 سال اخیر فعالیت ورزشی داشته باشند
بیماری های قلبی عروقی داشته باشند بیماری دیابت و فشار خون داشته باشند دخانیات و الکل مصرف کنند بطور منظم دارو مصرف کنند به صورت منظم در 1 سال اخیر فعالیت ورزشی داشته باشند
Ethics committees
#1
2017-12-19, 1396/09/28
2025-10-03, 1404/07/11
20172025-1210-1903 00:00:00
Health conditions studied
#1
Effects of resistance training on serum levels of hs-CTnI, NT-proBNP, GDF-15 and cardiac injury markers in healthy and diabetic elderly men
Effects of resistance training on serum levels of hs-CTnI, NT-proBNP, GDF-15 and cardiac injury markers in healthy and diabetic elderly men
آثار تمرین مقاومتی بر سطوح سرمی hs-CTnI, NT-proBNP, GDF-15 و مارکرهای آسیب قلبی در مردان سالمند سالم و دیابتی
آثار تمرین مقاومتی بر سطوح سرمی hs-CTnI, NT-proBNP, GDF-15 و مارکرهای آسیب قلبی در مردان سالمند سالم و دیابتی
Secondary outcomes
#1
Reducing the risk of cardiovascular disease
Reducing the risk of cardiovascular disease
کاهش خطر بیماری های قلبی عروقی
کاهش خطر بیماری های قلبی عروقی
The beginning and end of the exercise
The beginning and end of the exercise
ابتدا و انتهای تمرین
ابتدا و انتهای تمرین
Blood collection using laboratory kits
Blood collection using laboratory kits
خون گیری با استفاده از کیت های آزمایشگاهی
خون گیری با استفاده از کیت های آزمایشگاهی
#2
empty
empty
empty
empty
empty
empty
#3
empty
empty
empty
empty
empty
empty
#4
empty
empty
empty
empty
empty
empty
#5
empty
empty
empty
empty
empty
empty
#6
empty
empty
empty
empty
empty
empty
Protocol summary
Study aim
The purpose of this study to investigate the effect of resistance training on serum levels High Sensitivity-Cardiac Troponin I, N-terminal proBrain Natriuretic Peptid, growth-differentiation factor 15 and The markers of heart damage are in Healthy and diabetic elderly men.
Design
This is a semi-experimental study with pretest design with post-test. The statistical population of this study is male elderly men aged 65-78 years old in Karaj. Twenty-four subjects were selected as the sample and randomly divided into two groups of resistance training (12 subjects) and control (12 people)
Settings and conduct
At the beginning and the end of the exercises, blood samples are taken. Exercises in the gym are the place for elderly people in Alborz.
Participants/Inclusion and exclusion criteria
Inclusion criteria: range from 65 to 78 years old.
Exclusion criteria: illness, alcohol and tobacco use, and regular exercise in the past year
Intervention groups
Resistance training
Main outcome variables
hs-CTnI, NT-proBNP, GDF-15, creatine kinase MB, total creatine kinase, and lactate dehydrogenase are measured in both pre and post training sessions.
General information
Reason for update
In the name of God
Given that the Vice Chancellor for Research and Technology of Guilan University of Medical Sciences sent a comprehensive letter to that center to obtain a clinical trial code, I conducted research and sampling on healthy and diabetic elderly people. Unfortunately, I have encountered a problem in publishing the second article related to the section on diabetic elderly people, and the editor of the journal has requested that the words "healthy and diabetic" be added. In addition, given that it was the first time I was registering the research subject information to obtain a clinical trial code, I had completed some parts incompletely, which is currently being corrected. Please instruct the esteemed clinical trial code registrar to change the subject to the following form so that my problem can be resolved (the words "healthy and diabetic" should be added to the end of the subject): "Effects of resistance training on serum levels of hs-CTnI, NT-proBNP, GDF-15 and cardiac injury markers in healthy and diabetic elderly men"
Acronym
IRCT registration information
IRCT registration number:IRCT20180819040831N1
Registration date:2018-09-03, 1397/06/12
Registration timing:registered_while_recruiting
Last update:2025-10-25, 1404/08/03
Update count:1
Registration date
2018-09-03, 1397/06/12
Registrant information
Name
Bahman Mirzaei
Name of organization / entity
Guilan University
Country
Iran (Islamic Republic of)
Phone
+98 26 3736 0308
Email address
e.rangraz56@gmail.com
Recruitment status
Recruitment complete
Funding source
Expected recruitment start date
2018-08-31, 1397/06/09
Expected recruitment end date
2018-11-02, 1397/08/11
Actual recruitment start date
empty
Actual recruitment end date
empty
Trial completion date
empty
Scientific title
The effects of resistance training on serum levels of hs-CTnI, NT-proBNP, GDF-15, and cardiac damage markers in healthy and diabetic elderly men
Public title
The effects of resistance training on serum levels of hs-CTnI, NT-proBNP, GDF-15, and cardiac damage markers
Purpose
Prevention
Inclusion/Exclusion criteria
Inclusion criteria:
Men aged between 65 and 78 years old
Exclusion criteria:
Have cardiovascular disease
Use tobacco and alcohol
Have been regularly involved in sports activities in the last 1 year
Age
From 65 years old to 78 years old
Gender
Male
Phase
N/A
Groups that have been masked
No information
Sample size
Target sample size:
24
Randomization (investigator's opinion)
Not randomized
Randomization description
Blinding (investigator's opinion)
Not blinded
Blinding description
Placebo
Not used
Assignment
Single
Other design features
Resistance exercises
Secondary Ids
empty
Ethics committees
1
Ethics committee
Name of ethics committee
Ethics committee of Guilan University of Medical Sciences
Street address
Km 5 Rasht, University of Guilan
City
Guilan
Province
Guilan
Postal code
3187153704
Approval date
2025-10-03, 1404/07/11
Ethics committee reference number
IR.GUMS.REC
Health conditions studied
1
Description of health condition studied
Effects of resistance training on serum levels of hs-CTnI, NT-proBNP, GDF-15 and cardiac injury markers in healthy and diabetic elderly men
ICD-10 code
ICD-10 code description
Primary outcomes
1
Description
hs-CTnI
Timepoint
Before and after exercise
Method of measurement
Human cardiac troponin I(hs-CTnI) (Diasorin Kit)high sensitive
2
Description
NT-proBNP
Timepoint
Before and after exercise
Method of measurement
Human N-terminal pro-brain natriuretic peptide,NT-proBNP, ELISA kit
3
Description
Isophorm growth differentiation factor 15
Timepoint
Before and after exercise
Method of measurement
Human growth differentiation factor 15, ELISA kit
4
Description
Creatine kinase type MB
Timepoint
Before and after exercise
Method of measurement
creatine kinase-myocardial band, kit Pars test
5
Description
Total creatine kinase level
Timepoint
Before and after exercise
Method of measurement
creatine kinase, kit Pars test
6
Description
Lactate dehydrogenase
Timepoint
Before and after exercise
Method of measurement
Using the Pars kit, test lactate dehydrogenase
Secondary outcomes
1
Description
Reducing the risk of cardiovascular disease
Timepoint
The beginning and end of the exercise
Method of measurement
Blood collection using laboratory kits
Intervention groups
1
Description
Intervention group: Perform exercises for 8 weeks and 3 sessions per week. The exercise protocol for these people includes 5 minutes of warming (jumping or cycling), the main body of the training and 5 minutes of cool down (stretching). The main motions used are 3 sets with 10 repetitions of 70% 1RM including eight movements of the foot press, forehead, back, leg, chest, boat, arm and arm front. The exercise protocol is a gradual increase in severity and duration for the first two weeks in order to minimize muscle pain and reduce damage. Between each set is one minute and there is a two minute rest between each of the moves. Resistance increases when the subject is able to complete 10 repetitions correctly in the third set for 2 consecutive sessions, and the 1RM at the end of the fourth week is measured and the intensity of the exercise is adjusted in the same way. 48 hours after the last meeting of the protocols in the present study, all measurements of the body composition and biochemical evaluations (in the pre-test) are repeated again.
Category
Other
Recruitment centers
1
Recruitment center
Name of recruitment center
Kahrizak Elderly Care Center
Full name of responsible person
Hakimi Hosein
Street address
Mohammad Shahr, at the end of Golestan St., Beginning of Isfahan Street
City
Mohammad shahr
Province
Alborz
Postal code
31845167
Phone
+98 26 3630 9171
Fax
+98 26 3630 1859
Email
Kahraj@kahrizak.com
Sponsors / Funding sources
1
Sponsor
Name of organization / entity
Guilan University of Medical Sciences
Full name of responsible person
Nemati Shadman
Street address
Rasht, Namjoo Street, Shahid Siadati St., Facing the Shahrivar Hospital - Old Building of School of Public Health
City
Rasht
Province
Guilan
Postal code
3187614991
Phone
+98 26 3736 0308
Fax
+98 28 3422 0835
Email
e.rangraz56@gmail.com
Grant name
Grant code / Reference number
Is the source of funding the same sponsor organization/entity?
Yes
Title of funding source
Guilan University of Medical Sciences
Proportion provided by this source
100
Public or private sector
Private
Domestic or foreign origin
Domestic
Category of foreign source of funding
empty
Country of origin
Type of organization providing the funding
Academic
Person responsible for general inquiries
Contact
Name of organization / entity
Guilan University
Full name of responsible person
Bahman Mirzaei
Position
Professor
Latest degree
Ph.D.
Other areas of specialty/work
Sport physiology
Street address
Km 5 of Rasht. Faculty of Physical Education and Sport Sciences
City
Guilan
Province
Guilan
Postal code
3187614991
Phone
+98 26 3736 0308
Fax
+98 28 3422 0835
Email
e.rangraz56@gmail.com
Web page address
http://jme.guilan.ac.ir
Person responsible for scientific inquiries
Contact
Name of organization / entity
Guilan University
Full name of responsible person
Bahman Mirzaei
Position
Professor
Latest degree
Ph.D.
Other areas of specialty/work
Sport physiology
Street address
Km 5 of Rasht. Faculty of Physical Education and Sport Sciences
City
Guilan
Province
Guilan
Postal code
3187614991
Phone
+98 26 3736 0308
Fax
+98 28 3422 0835
Email
e.rangraz56@gmail.com
Web page address
http://jme.guilan.ac.ir/
Person responsible for updating data
Contact
Name of organization / entity
The University of Guilan
Full name of responsible person
Bahman Mirzaei
Position
Professor
Latest degree
Ph.D.
Other areas of specialty/work
Sport Physiology
Street address
Kil 5 Rasht - The University of Guilan
City
Rasht
Province
Guilan
Postal code
4199613776
Phone
+98 13336902748
Fax
+98 13 3369 0277
Email
e.rangraz56@gmail.com
Web page address
https://www.guilan.ac.ir
Sharing plan
Deidentified Individual Participant Data Set (IPD)
No - There is not a plan to make this available
Justification/reason for indecision/not sharing IPD