The comparison of the effects of vitamin D-omega-3 fatty acids co-supplementation with vitamin D and omega-3 fatty acids alone on anthropometric, metabolic stress, hypertension and and serum androgen profile in women with poly cystic ovary syndrome

The comparison of the effects of vitamin D-omega-3 fatty acids co-supplementation with vitamin D and omega-3 fatty acids alone on anthropometric, metabolic stress, hypertension and and serum androgen profile in women with poly cystic ovary syndrome

This study was a randomized double-blind placebo-controlled Parallel 4 group of eight weeks clinical trial

At the beginning of the present study,all patients were asked to carry out their capsules in second (end of week 4) and third (end of Eighth week) to ensure full consumption . Follow patients to control them in terms of taking capsules, the possibility of severe side effects or symptoms of poisoning with supplements used and to prevent the loss of samples, each week to telephone and also through referring patients to Shahid Motahari Clinic in Shiraz at the end of the fourth and eighth weeks

Inclusion criteria This syndrome is defined by the Rotterdam Diagnostic Criteria by Gynecologist Excluding any drug or surgical treatment to treat clinical symptoms associated with polycystic ovary syndrome except ocp ; No history of any allergy, intolerance or harmful drug reaction to the studied supplements, Age range ..18-45 ; Ability to understand study objectives and provide written informed consent Being within the BMI range of 18.5-45 ; Residence in Shiraz and willingness to participate in the study Exclusion criteria The incidence of severe side effects or symptoms of poisoning with supplements used during the study period;Initiate intake or any changes in the type or dosage;Getting pregnant during the study period;Non-adherence to the study protocol

The four groups of each group are 20 (a) vitamin D and omega-3, B) vitamin D and pelacebo omega-, 3 C) Omega-3 and pelacebo vitaminD, d)pelacebo

metabolic indicators, blood pressure

samples were categorized using a Permuted block randomization method (29) based on whether or not using OCP by using Random Allocation Software as 1: 1: 1: 1 and equally to one of the 4 groups

Before the beginning of an individual study other than the researcher who was unaware of the objectives of the study, without notifying the researcher, vitamin D capsules in cans labeled A and placebo capsule of vitamin D in cans labeled B and capsules of omega-3 fatty acids in cans with the label C and placebo capsules put omega-3 fatty acids in cans labeled D.On the other hand, the usage instructions for each of the cans (including the number of capsule to be received daily or weekly, and of course, how they are used) were placed inside each cans.Then, according to the design of the study, the subjects received one of the possible AC combinations (which can be specific to one of the vitaminD-omega-3 or placebo groups),AD, CB, Ador BD.