History
# Registration date Revision Id
2 2020-02-04, 1398/11/15 121992
1 2020-02-01, 1398/11/12 120239
Changes made to previous revision
This is the first revision

Protocol summary

Study aim
Comparison of the effect of pelvic physiotherapy with standard medical care on functional constipation in children
Design
Clinical trial, interventional, parallel groups, single blind, quality, Quadratic block randomization
Settings and conduct
Outpatient patients referred to gastroenterology clinic of Shahid Beheshti hospital of Kashan University of Medical Sciences are first visited and examined by pediatric gastroenterologist. Questionnaires are prepared and then randomly enrolled into two groups. The group is treated with polyethylene glycol as standard drug treatment and the second group is given pelvic physiotherapy.
Participants/Inclusion and exclusion criteria
1. Children 6 to 15 years 2. Children with chronic functional constipation
Intervention groups
Pelvic physiotherapy group and standard medical care group (recipient of polyethylene glycol powder)
Main outcome variables
Pediatric Constipation Score

General information

Reason for update
Acronym
IRCT registration information
IRCT registration number: IRCT20191111045403N1
Registration date: 2020-02-01, 1398/11/12
Registration timing: registered_while_recruiting

Last update: 2020-02-01, 1398/11/12
Update count: 1
Registration date
2020-02-01, 1398/11/12
Registrant information
Name
Amin ali Rahimi
Name of organization / entity
Country
Iran (Islamic Republic of)
Phone
+98 31 5554 0021
Email address
rahimi-a@mail.kaums.ac.ir
Recruitment status
Recruitment complete
Funding source
Expected recruitment start date
2020-01-30, 1398/11/10
Expected recruitment end date
2020-03-29, 1399/01/10
Actual recruitment start date
empty
Actual recruitment end date
empty
Trial completion date
empty
Scientific title
Effectiveness of pelvic physiotherapy in children With functional constipation compared with standard medical care
Public title
Effectiveness of pelvic physiotherapy in constipation
Purpose
Treatment
Inclusion/Exclusion criteria
Inclusion criteria:
children With functional constipation children in 5 -15 old years
Exclusion criteria:
Children with metabolic and endocrine diseases such as hypothyroidism, diabetes mellitus, diabetes mellitus and hypercalcemia, etc. Children with neurological or psychiatric illnesses such as spina bifida, cerebral palsy, anorexia nervosa, autism, neurofibromatosis, etc. Children with intestinal disease such as Hirschsprung's disease Children with Down Syndrome A history of intestinal surgery Children taking constipation drugs (anticholinergics, phenytoin, antidepressants, chemotherapy drugs such as vincristine, etc.) Children with fecal impaction Patients with a specific diet History of pelvic physiotherapy due to bladder or bowel problems during the past 3 months Perform any other remedies for constipation during the study Other Causes of Constipation, such as Scleroderma, Sexual Abuse, Cystic Fibrosis, and Dietary Protein Allergies
Age
From 6 years old to 15 years old
Gender
Both
Phase
3
Groups that have been masked
  • Outcome assessor
  • Data analyser
Sample size
Target sample size: 68
Randomization (investigator's opinion)
Randomized
Randomization description
Samples will be selected by simple non-probability sampling method and then allocaetd into two groups by four-block randomization method.
Blinding (investigator's opinion)
Single blinded
Blinding description
Allocations were randomly assigned to two groups using computer software previously specified by the statistical specialist and patients would be assigned to either group A or group B, outcome assessor and data analyzer Which group of patients received drug treatment or physiotherapy is not known. This study is a unilateral blinded researcher.
Placebo
Not used
Assignment
Parallel
Other design features

Secondary Ids

empty

Ethics committees

1

Ethics committee
Name of ethics committee
کمیته اخلاق دانشگاه علوم پزشکی کاشان
Street address
3km of Ravand Road - pezeshk Boulevard - Faculty of Medicine
City
Kashan
Province
Isfehan
Postal code
88715973474
Approval date
2019-10-06, 1398/07/14
Ethics committee reference number
IR.KAUMS.REC.1398.040

Health conditions studied

1

Description of health condition studied
Functional constipation in children
ICD-10 code
K59.09
ICD-10 code description
constipation

Primary outcomes

1

Description
Pediatric Constipation Score
Timepoint
At the beginning of the study(before intervention) and at 2 and 6 months after intervention
Method of measurement
Pediatrics Incontinence/Constipation Score Questionnaire(PICS)

Secondary outcomes

1

Description
Quality of life score
Timepoint
At the beginning of the study(before intervention) and at 2 and 6 months after intervention
Method of measurement
Based on the Quality of Life Questionnaire in Constipation Patients (PAC-QOL)

2

Description
Abdominal pain score
Timepoint
At the beginning of the study (before intervention) and at 2 and 6 months after intervention
Method of measurement
Abdominal pain based on the Visual Analog Scale and Wong-baker FACES

3

Description
Prebaseline pelvic floor muscles activity
Timepoint
At the beginning of the study (before the intervention) and after the intervention
Method of measurement
Surface Electromyography Based on millivolt

4

Description
Postbaseline pelvic floor muscles activity
Timepoint
At the beginning of the study (before the intervention) and after the intervention
Method of measurement
Surface Electromyography Based on millivolt

5

Description
Endurance of pelvic floor muscles
Timepoint
At the beginning of the study (before the intervention) and after the intervention
Method of measurement
Surface Electromyography Based on millivolt

6

Description
Strength of pelvic floor muscles
Timepoint
At the beginning of the study (before the intervention) and after the intervention
Method of measurement
Surface Electromyography Based on millivolt

7

Description
Pediatric Fecal Incontinence Scale
Timepoint
At the beginning of the study(before intervention) and at 2 and 6 months after intervention
Method of measurement
Pediatrics Incontinence/Constipation Score Questionnaire(PICS)

Intervention groups

1

Description
Intervention group: Pelvic Physiotherapy Receiving Group
Category
Treatment - Other

2

Description
Intervention group: Group receiving drug therapy
Category
Treatment - Drugs

Recruitment centers

1

Recruitment center
Name of recruitment center
Specialty Gastroenterology Clinic Shahid Beheshti Hospital Kashan University of Medical Sciences
Full name of responsible person
Abbas Taghavi Ardakani ; Seyed Ramin Madani
Street address
Faculty of Medicine - Kashan University of Medical Sciences -pezeshk Blvd - 3km of Ravand Road
City
Kashan
Province
Isfehan
Postal code
88715973474
Phone
+98 31 5562 1550
Email
medicine@kaums.ac.ir

Sponsors / Funding sources

1

Sponsor
Name of organization / entity
Kashan University of Medical Sciences
Full name of responsible person
Hamid Reza Banafsheh
Street address
Faculty of Medicine - Kashan University of Medical Sciences -pezeshk Blvd - 3km of Ravand Road
City
Kashan
Province
Isfehan
Postal code
88715973474
Phone
+98 31 5510 9999
Email
medicine@kaums.ac.ir
Grant name
Grant code / Reference number
Is the source of funding the same sponsor organization/entity?
Yes
Title of funding source
Kashan University of Medical Sciences
Proportion provided by this source
100
Public or private sector
Public
Domestic or foreign origin
Domestic
Category of foreign source of funding
empty
Country of origin
Type of organization providing the funding
Academic

Person responsible for general inquiries

Contact
Name of organization / entity
Kashan University of Medical Sciences
Full name of responsible person
Amin Ali Rahimi
Position
Assisstant
Latest degree
Medical doctor
Other areas of specialty/work
Pediatrics
Street address
Faculty of Medicine, Kashan University of Medical Sciences, Medical Blvd., 3km of Ravand Road
City
Kashan
Province
Isfehan
Postal code
88715973474
Phone
0098 31 55540021-25
Email
Rahimi-a@mail.kaums.ac.ir

Person responsible for scientific inquiries

Contact
Name of organization / entity
Kashan University of Medical Sciences
Full name of responsible person
Amin Ali Rahimi
Position
Assistant
Latest degree
Medical doctor
Other areas of specialty/work
Pediatrics
Street address
Faculty of Medicine- Kashan University of Medical Sciences- pezeshk Blvd- 3km of Ravand Road
City
Kashan
Province
Isfehan
Postal code
88715973474
Phone
0098 31 55540021-25
Email
Rahimi-a@mail.kaums.ac.ir

Person responsible for updating data

Contact
Name of organization / entity
Kashan University of Medical Sciences
Full name of responsible person
Amin Ali Rahimi
Position
Assistant
Latest degree
Medical doctor
Other areas of specialty/work
Pediatrics
Street address
Faculty of Medicine, Kashan University of Medical Sciences, pezeshk Blvd., 3km of Ravand Road
City
Kashan
Province
Isfehan
Postal code
88715973474
Phone
0098 31 55540021-25
Email
Rahimi-a@mail.kaums.ac.ir

Sharing plan

Deidentified Individual Participant Data Set (IPD)
Undecided - It is not yet known if there will be a plan to make this available
Study Protocol
Undecided - It is not yet known if there will be a plan to make this available
Statistical Analysis Plan
Undecided - It is not yet known if there will be a plan to make this available
Informed Consent Form
Undecided - It is not yet known if there will be a plan to make this available
Clinical Study Report
Undecided - It is not yet known if there will be a plan to make this available
Analytic Code
Undecided - It is not yet known if there will be a plan to make this available
Data Dictionary
Undecided - It is not yet known if there will be a plan to make this available
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