History
# Registration date Revision Id
2 2022-01-15, 1400/10/25 213636
1 2021-05-31, 1400/03/10 184734
Changes made to previous revision
This is the first revision

Protocol summary

Study aim
Determining the therapeutic effects of Iranian "Nava" musical dastgah in the treatment of sciatica and comparing its efficacy with the common treatment
Design
Clinical trial with parallel control group, performed on 112 patients, outcome assessment is blind
Settings and conduct
This study is performed as a clinical trial on patients referred to the Neurosurgery Clinic of Hazrat Rasoul Akram Hospital and the Traditional Medicine Health Center affiliated to Iran University of Medical Sciences. In the intervention group, in addition to the usual treatment, patients listen to a five-minute piece of Iranian "Nava" musical dastgah once a day. And in the control group, patients receive only the usual treatment. The duration of this treatment period is ten days.
Participants/Inclusion and exclusion criteria
Diagnosis of sciatica (low back pain spreading to the lower limbs below the knee) based on clinical examination or MRI; less than two weeks after the onset of pain (continuous or intermittent); age: 35 to 65 years old; moderate to severe pain intensity at the start of treatment (VAS greater than or equal to 4); no indication for lumbar spine surgery; no hearing problems; no history of seizures and noise-aggravated brain lesions; fluency in Persian.
Intervention groups
Intervention group: along side receiving standard treatment and care, every night, the recruits in the intervention group listens to a musical piece in "Mirza abdollah" Radif and "Nava" Dastgah for 5 minutes. This piece is performed by Master Aliasghar Bayani using a "Setar" instrument. Control group: the recruits in control group receive standard treatment and care. the standard care includes home rest, warm compression of the pain field, and 500 mg acetaminophen tablet intake (1-4 tabs per day in relation to the patient's pain).
Main outcome variables
(Visual Analogue Scale) VAS; Roland- Morris disability questionnaire score

General information

Reason for update
Acronym
IRCT registration information
IRCT registration number: IRCT20210226050508N1
Registration date: 2021-05-31, 1400/03/10
Registration timing: prospective

Last update: 2021-05-31, 1400/03/10
Update count: 1
Registration date
2021-05-31, 1400/03/10
Registrant information
Name
mona haghighi
Name of organization / entity
Country
Iran (Islamic Republic of)
Phone
+98 21 6656 0356
Email address
dr.mona.haghighi@gmail.com
Recruitment status
Recruitment complete
Funding source
Expected recruitment start date
2021-06-22, 1400/04/01
Expected recruitment end date
2022-02-20, 1400/12/01
Actual recruitment start date
empty
Actual recruitment end date
empty
Trial completion date
empty
Scientific title
Assessment of therapeutic effects of Iranian Nava musical dastgah on Sciatica and comparing it with the conventional medical treatment: a randomised control trial
Public title
Assessment of therapeutic effects of Iranian Nava musical dastgah on Sciatica and comparing it with the conventional medical treatment: a randomised control trial
Purpose
Treatment
Inclusion/Exclusion criteria
Inclusion criteria:
Diagnosis of sciatica or radicular low back pain (low back pain spreading to the lower limbs below the knee) based on clinical examination or MRI Less than two weeks after the onset of pain (continuous or intermittent) Age: 35 to 65 years old Moderate to severe pain intensity at the start of treatment (VAS greater than or equal to 4) No indication for lumbar spine surgery No hearing problems No history of seizures and noise-aggravated brain lesions(Reflex Epilepsy ) Fluency in Persian
Exclusion criteria:
Age less than 35 and more than 65 History of previous lumbar spine surgery Symptoms of cauda equina‏ syndrome (numbness and weakness of both legs, anal pain, perineal anesthesia, sphincter paralysis) Existence of low back pain with specific causes such as fractures, cancer, systemic inflammation and rheumatic diseases, infection and severe degenerative changes Symptoms during treatment that the doctor thinks need further investigation and intervention, such as diseases of other organs Pregnancy Causes hearing problems or noise-aggravated brain damage A history of corticosteroid or opioid use in the last six weeks for any reason Patient dissatisfaction
Age
From 35 years old to 65 years old
Gender
Both
Phase
N/A
Groups that have been masked
  • Care provider
  • Outcome assessor
  • Data analyser
Sample size
Target sample size: 112
Randomization (investigator's opinion)
Randomized
Randomization description
Randomisation method: stratified randomization; unit of randomization: odds and even; randomization layers: moderate to severe pain severity; randomization tool: first, the recruits are divided into moderate and severe groups according to the pain severity, then in each category, randomization is performed by block method. Quadruple blocks are selected using a random number table and a random list is prepared. Concealment: a sealed envelope is used. The patient number is written on the envelope and inside the A&B group envelope.
Blinding (investigator's opinion)
Double blinded
Blinding description
In this study, those who cared for patients and provided them with lottery bags and music, and those who collected data and analyzers did not know the study groups.
Placebo
Not used
Assignment
Parallel
Other design features
This is the first clinical study dedicated specifically to the therapeutic effects of the Iranian Nava music Dastgah.

Secondary Ids

empty

Ethics committees

1

Ethics committee
Name of ethics committee
Ethics committee of Iran University of Medical Sciences
Street address
13th floor, Block A, Headquarters of the Ministry of Health, Treatment and Medical, Simaye Iran St, Ghods town
City
Tehran
Province
Tehran
Postal code
1467664961
Approval date
2021-02-13, 1399/11/25
Ethics committee reference number
IR.IUMS.REC.1399.1237

Health conditions studied

1

Description of health condition studied
Low back pain (Sciatica)
ICD-10 code
M54.30
ICD-10 code description
Sciatica, unspecified side

Primary outcomes

1

Description
VAS (Visual Analogue Scale)
Timepoint
At the beginning of the study, the tenth day and the thirtieth day
Method of measurement
Visual Analogue Scale questionnaire

2

Description
Roland- Morris disability questionnaire score
Timepoint
At the beginning of the study, the tenth day and the thirtieth day
Method of measurement
Roland- Morris disability questionnaire

Secondary outcomes

1

Description
Speilberger State – Trait Anxiety Inventory score
Timepoint
At the beginning of the study, the tenth day and the thirtieth day
Method of measurement
Speilberger State – Trait Anxiety Inventory

2

Description
Daily consumption of analgesic medication
Timepoint
At the beginning of the study, the tenth day and the thirtieth day
Method of measurement
Questionnaire

3

Description
Salmannezhad Mizaj Identification Questionnaire score
Timepoint
At the beginning of the study
Method of measurement
Salmannezhad Mizaj Identification Questionnaire in Persian Medicine

Intervention groups

1

Description
Intervention group: along side receiving standard treatment and care, every night, the recruits in the intervention group listens to a musical piece in "Mirza abdollah" Radif and Iranian "Nava" musical dastgah for 5 minutes. This piece is performed by Master Aliasghar Bayani using a "Setar" instrument.
Category
Treatment - Other

2

Description
Control group: The recruits in control group receive standard treatment and care. the standard care includes home rest, warm compression of the pain field, and 500 mg acetaminophen tablet intake (1-4 tabs per day in relation to the patient's pain).
Category
Treatment - Drugs

Recruitment centers

1

Recruitment center
Name of recruitment center
Hazrat Rasool Akram Hospital
Full name of responsible person
Hasan Ghandhari
Street address
Rasoul Akram Hospital, Maziar Mansouri St., Sattar Khan Ave..
City
Tehran
Province
Tehran
Postal code
۱۴۴۵۶۱۳۱۳۱
Phone
+98 21 6650 2248
Fax
+98 21 6650 2248
Email
hrmc@iums.ac.ir
Web page address
https://hrmc.iums.ac.ir/

2

Recruitment center
Name of recruitment center
Behesht Iranian traditional medicine healthcare centre
Full name of responsible person
Elham Akhtari
Street address
No. 847, Behesht St., South Side City Park, Vahdat Eslami St., Hassan Abad Square,
City
Tehran
Province
Tehran
Postal code
۱۱۱۴۷۳۳۳۱۱
Phone
+98 21 5558 0388
Email
stm@iums.ac.ir
Web page address
https://stm.iums.ac.ir/

Sponsors / Funding sources

1

Sponsor
Name of organization / entity
Iran University of Medical Sciences
Full name of responsible person
مسعود سلیمانی
Street address
Iran University of Medical Sciences Shahid Hemmat Highway
City
tehran
Province
Tehran
Postal code
۱۴۴۹۶۱۴۵۳۵
Phone
+98 21 8670 2504
Fax
+98 21 8862 2307
Email
research-m‌‌‌@iums.ac.ir
Web page address
https://vcr.iums.ac.ir/
Grant name
Grant code / Reference number
Is the source of funding the same sponsor organization/entity?
Yes
Title of funding source
Iran University of Medical Sciences
Proportion provided by this source
100
Public or private sector
Public
Domestic or foreign origin
Domestic
Category of foreign source of funding
empty
Country of origin
Type of organization providing the funding
Academic

Person responsible for general inquiries

Contact
Name of organization / entity
Iran University of Medical Sciences
Full name of responsible person
Mona Haghighi
Position
Traditional Iranian medicine Assistant
Latest degree
Medical doctor
Other areas of specialty/work
Traditional Medicine
Street address
School of Traditional Medicine, No 847, Behesht St. South Side of Shahr Park, Vahdat-e-Islami St., Hasan Abad Sq., Tehran, Iran.
City
Tehran
Province
Tehran
Postal code
1114733311
Phone
+9855580388
Email
dr.mona.haghighi@gmail.com
Web page address

Person responsible for scientific inquiries

Contact
Name of organization / entity
Iran University of Medical Sciences
Full name of responsible person
Mona Haghighi
Position
Iranian traditional medicine assistant
Latest degree
Medical doctor
Other areas of specialty/work
Traditional Medicine
Street address
No 847, Behesht St. South Side of Shahr Park, Vahdat-e-Islami St., Hasan Abad Sq., Tehran, Iran
City
Tehran
Province
Tehran
Postal code
1114733311
Phone
+98 21 5558 0388
Email
dr.mona.haghighi@gmail.com
Web page address

Person responsible for updating data

Contact
Name of organization / entity
Iran University of Medical Sciences
Full name of responsible person
Mona Haghighi
Position
Iranian traditional medicine assistant
Latest degree
Medical doctor
Other areas of specialty/work
Traditional Medicine
Street address
No 847, Behesht St. South Side of Shahr Park, Vahdat-e-Islami St., Hasan Abad Sq., Tehran, Iran
City
Tehran
Province
Tehran
Postal code
1114733311
Phone
+98 21 5558 0388
Email
dr.mona.haghighi@gmail.com

Sharing plan

Deidentified Individual Participant Data Set (IPD)
Undecided - It is not yet known if there will be a plan to make this available
Study Protocol
Undecided - It is not yet known if there will be a plan to make this available
Statistical Analysis Plan
Undecided - It is not yet known if there will be a plan to make this available
Informed Consent Form
Undecided - It is not yet known if there will be a plan to make this available
Clinical Study Report
Undecided - It is not yet known if there will be a plan to make this available
Analytic Code
Undecided - It is not yet known if there will be a plan to make this available
Data Dictionary
Undecided - It is not yet known if there will be a plan to make this available
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