Evaluation of the effect of local injection of dexamethasone with bupivacaine at pre-peritoneal laparoscopic ports on laparoscopic complications after laparoscopic cholecystectomy a randomized controlled clinical trial.

Study the effect of dexamethasone and bupivacaine pre-peritoneal injection at the site of laparoscopic ports, on complications after laparoscopic cholecystectomy in Isfahan in 1400

Clinical trial, with control group, with parallel groups, three-way blind, randomized, phase 3 on 96 patients. Random numbers method which carried out at an external site (miraclesalad) is used for randomization.

In order to evaluate the effect of bupivacaine with and without dexamethasone on pain after laparoscopic cholecystectomy in the operating room by one of the trained technicians without informing patients and surgeon and researcher in one group bupivacaine + dexamethasone injection and in the other group bupivacaine It is performed alone and in the first 24 hours, the amount of pain and the need for pain in patients is evaluated.

The inclusion criteria is all the patients undergoing laparoscopic cholecystectomy with a diagnosis of biliary colic or chronic cholecystitis in 1400. Criteria for not including patients in our study are: diagnosis of acute cholecystitis along with findings such as, leukocytosis and high ESR and CRP, gangrene, empyema and evidence of bile in the abdominal cavity during surgery, known allergy to local anesthetics, open surgery and diabetic patients and those with dirty wounds and open cholecystectomy.

7 mg bupivacaine is injected at the lower ports and 3 mg bupivacaine at the upper ports. Then, only in the "bupivacaine + dexamethasone" group, the dose of dexamethasone is determined based on the patient's weight at 0.2 mg per kg and is divided into four parts, and each part is injected at the site of a port.

Frequency of nausea and vomiting, relative pain intensity, mean of drug use and mean of BS after 24 hours in the two groups.

Patients will be randomly divided into two groups using computer random number method. This random distribution of patients will be done by an independent computer programmer using www.randomization.com.

On the day of surgery, one of the operating room technicians trained according to the instructions and based on the site www.randomization.com prepares the medicine for the group in which the patient is accidentally placed and then the surgeon injects it only without notice to the relevant place. Dexamethasone and bupivacaine are injected into a syringe, and to hide the volume of the drug, the syringes are covered with a dark coating and the syringe is identified only based on groups A and B. Slowly The patient and the data collector and the safety and data monitoring committee also do not know what the drug was.