the effect of dopamine agonists (cabergoline) on reducing pain in endometriosis patients

effect of dopamine agonists (cabergoline) on pain reduction in endometriosis patients.

A clinical trial with control and parallel groups, randomized, phase 3 on 72 patients. The permutation blocks method produced the sequence of randomly allocated people to the studied groups. A random allocation sequence of people was done using Random Allocation Software and a block size of four.

patients with endometriosis who refer to the gynecology clinic of Ghaem and Imam Reza (AS) hospitals are included in the study based on inclusion and exclusion criteria. Before starting treatment, on the first day of menstruation, the severity of dysmenorrhea pain in patients is measured using the VAS standard.

inclusion criteria: Diagnosis of clinical endometriosis by observing pain and tenderness in the pelvic examination along with endometriosis nodules in the vaginal examination, firm and motionless uterus and confirmed by ultrasound or MRI (observation of endometriosis cysts and nodules) Diagnosis of grade I-IV endometriosis based on r-ASRM criteria during diagnostic laparoscopy during the previous 12 months Dysmenorrhea complaints with EAPP score >30 or >40, normal pap smear. Exclusion criteria: endometriosis who were treated with GnRH agonist less than 6 months ago, or danazol or progesterone pills less than 3 months ago, or birth control pills less than 1 month ago.

Patients with endometriosis will be given dopamine agonists (cabergoline) 0.5 twice a week for three months and in Contol groups will be given the dingiest 2 milligrams once a day for three months.

EAPP on the first day of menstruation and at the end of the first, second, and third month is treatment.

In this study, the permutation blocks method was used to generate the sequence of random assignments of people to the studied groups. A random allocation sequence of people was done using Random Allocation Software and a block size of four. The permutation block method is one of the random allocation methods in which each block is selected as an integer multiple of the number of studied groups. In this study, there are four blocks: AABB, ABAB, BBAA, and BABA. One of the blocks is randomly selected. If the first block, AABB, is selected, the first and second person will be assigned to group A, and the third and fourth person will be assigned to group B. And this process continues until all samples are allocated. The feature of this method is that the two study groups will have equal numbers. Random Allocation Software is free software for creating a random sequence using scientific methods including the permutation block method for allocating subjects to treatment groups, which was developed by Dr. Mahmoud Saghaei (https://www.saghaei.net).