Investigating the effect of aromatherapy with rose essential oil on depression in patients referred to neurology clinics

So far, no specific complications have been observed in connection with the use of rose essential oil. Similarly, this drug has been used to reduce the symptoms of depression in animal models (21), but it has not been used to reduce the symptoms of depression in patients. Therefore, this study will be conducted with the aim of investigating the effect of rose essential oil on reducing depression symptoms in patients referred to the clinics of Arak University of Medical Sciences.

This research is a double-blind randomized clinical trial with a parallel control group, which will use a coin toss for randomization

Patients referred to the neuropsychiatric clinic affiliated to Arak University of Medical Sciences, whose depression disorder has been determined based on DSMVITR diagnostic criteria and after examination by a psychiatrist, are randomly assigned to two groups. And in two stages (day 0-30) their depression is measured.

 Age 18-70 years  Not having a psychotic phase  Absence of suicidal thoughts  No history of mental disorder  Not taking antidepressants  Absence of olfactory disorders  No history of allergy and eczema to rose  Being able to understand and write Persian language

The people of the control and intervention groups are taught to perform aromatherapy for one month, in this way, 2 drops of 2% rose essence produced by Barij Essence Company for the intervention group and the same amount of distilled water for the control group, with The dropper is poured on a 10 x 10 cm gas and it is connected to a distance of 20 cm from the subject's nose and on their shirt, and the patients inhale it for 20 minutes. They do this twice a day. The recovery rate will be evaluated after the intervention

Depression, age, sex, marriage, education, job

The request to update this protocol has various reasons, one of the most important of which is the disruption in sampling, which means that due to the long duration of the entire intervention, many participants did not finish the intervention at the beginning, and for this reason, the authors, citing Previous studies based on shorter intervention length (one month duration) decided to sample for the second time and with shorter intervention length. Therefore, please update the changes included in the method. The protocols with one month intervention and almost similar to the present study: IRCTID: IRCT20190305042936N1 IRCTID: IRCT20230702058649N1

In this research, coin tossing will be used for randomization. In this way, the first participant is placed randomly (coin toss) in one of the two intervention or control groups. In the next step, the participants will be distributed evenly between the two groups. In such a way that if the line comes for the first time and the researcher considers the line to be the entry into the control group, the subjects will be entered into the intervention group first and then the control group according to the order of entry into the study

Blinding in this study will be double blind. In order to reduce the error and bias in this clinical study, the intervention and control group (participants) will be blinded to the type of intervention using a placebo. Also, the plan executives are not included in the process of intervention by conducting the intervention by a researcher other than the people who prepare the draft of the article.

There is no further information."