Comparison of the effect of tow embryo transfer in the stage of blastocyst and sequential transfer of a cleavage-a blastocyst embryo on pregnancy outcomes Patients who are candidates for frozen embryo transfer and recurrent implantation failure; a randomized clinical trial

Comparison of the effect of transferring two embryos in the blastocyst stage and sequential transfer of one cleaved blastocyst embryo on pregnancy outcomes in patients who are candidates for frozen embryo transfer and have a history of repeated implantation failure.

The phase 3 clinical trial, with a control group, will be conducted in parallel on 140 patients. The randomization of the samples will be done with Weber's simple randomization method according to the generated list of random numbers. The list of random numbers will be generated using the Random Allocation 1 software by A statistical consultant will be produced.

This study is conducted by the clinical trial method in Yazd Research Institute of Reproductive Sciences. The studied and control cases will be selected from among the people with poor ovarian response referring to the infertility clinic who are candidates for assisted reproductive methods. People who meet the criteria for entering the study are divided into two groups: blastocyst and sequential transfer.

Women under 45 years of age with frozen embryos and a history of 2 implantation failures

Eligible people who have at least 4 frozen embryos are randomly placed in two consecutive transfer groups of one cleavage embryo and one blastocyst embryo and two blast embryos. In the blastocyst group 5 days after the start of progesterone and in the consecutive group once 3 days after the start Progesterone and once 5 days after the start of progesterone, embryo transfer takes place

Clinical pregnancy

End of patient admission and end of clinical trial

In this study, using the simple randomization method using the Random Allocation1 software (http://random-allocation software.informer.com\1) and based on the simple randomization method, the list of samples in the two groups studied by the expert Statistics will be generated. In this software, in order to generate a list of random numbers, first specify the number of groups to be studied as 2 and the total number of samples required as 140 people, and then from the list of sample randomization methods, the method (simple randomization method in parallel group) by considering the same number of samples in the groups. Then a random list will be generated based on the groups and the number of samples in each group. Randomly and after obtaining informed consent by the researcher, they are assigned to two groups. The sealed envelope method is used for concealment. Then a random list will be generated based on the number of samples in each group

All participant data sets are to be shared

2 months after the result publication

In order to receive data or other study documents, researchers working in academic and scientific institutions are allowed to apply

To evaluate the accuracy of the data and use data to complete other researches

Yazd Reproductive Sciences Institute, Bouali Ave, Yazd, Iran

Request from the Research Deputy, submitted to the Research Council of the Center if the request accepts its referral to the security and after completion of the relevant forms, the request is referred to the research experts and then get the data.