Evaluation of the effect of aloe vera and cinnamon on stimulation and moisture absorption in oral mucosa: A double-blind clinical trial

Identifying the effects of aloe vera and cinnamon on stimulating and moisturizing the oral mucosa

80 people who participated in the study were divided into 4 groups, the 4th group is considered as the control group

double-blind clinical trial study in the Faculty of Dentistry of Kerman , which is conducted on people with dry mouth in 4 groups: aloe vera extract, cinnamon extract, 50% solution of aloe vera extract and cinnamon, and negative control. XI questionnaire, visual scale (VAS), OHIP-14 questionnaire are used to evaluate dry mouth. In order to check the amount of saliva secretion before and after the intervention, a spitting test is performed. Both participants and investigators will be blinded to treatment assignment. Block randomization is used to control the effect of confounders. In this way, first, a sequence of random numbers of four is generated, and then, after registering the person, the researcher contacts the statistics expert based in the research center, and the person's group is determined, and the desired spray is given to the person.

Inclusion criteria: Patients between 18 years old and older with dry mouth Exclusion criteria: pregnancy, allergy to cinnamon or aloe vera, history of radiotherapy and chemotherapy, uncontrolled chronic disease and HIV, hepatitis C or hepatitis B infection.

Intervention group 1 includes patients with dry mouth, who receive the intervention of aloe vera extract. Intervention group 2 includes patients with dry mouth, who receive cinnamon extract intervention. Intervention group 3 includes patients with dry mouth, who receive the intervention of the combination of cinnamon extract and aloe vera. The control group includes patients with dry mouth, who receive normal saline intervention

dry mouth

Randomization method and description of each method: block randomization Randomization Unit: Individual For randomization, one letter from A, B, C, D is assigned to each group. Then 76 envelopes containing one of the 4 letters A, B, C, D are prepared in the number of 19 for each group and are placed inside a box. When each person enters the study, an envelope is randomly selected and opened. and the person is assigned to that group. The study groups will remain confidential until after the analysis of the study results

In order to blind the researcher and volunteers to participate in the study, the sprays are numbered with numbers one to four. Barij essence is added to all groups to equalize the smell and taste

Participant data file, part of the data such as information related to the main outcome.

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Correspondence with the corresponding author Shahla Kakoei 09131408974 skakoei@gmail.com

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