Comparison of the effects of ginger and dexamethasone and ondansetron and promethazine in reducing postoperative nausea and vomiting in patients undergoing hysterectomy

Comparison of the effects of ginger and dexamethasone and ondansetron and promethazine in reducing postoperative nausea and vomiting in patients undergoing hysterectomy

The study will be double blind and clinical trial.100 patients will be randomly divide into 4 groups. The groups are parallel. The trial phase is 3.

Patients who are candidates for hysterectomy at Sina Rezaei Ashtiani Hospital in Arak are divided into 4 groups using simple randomization with the envelope method. The study is double-blind, and blinding of the analyzer, outcome evaluator, and participant is performed.

Inclusion Criteria: no history of cancer, no history of high blood pressure, 40 to 60 years, platelet count above 100000, no history of intestinal obstruction and hepatitis, no use of anti-nausea and anti-vomiting drugs or drugs that induce them, no long-term treatment with corticosteroid drugs, no history of allergy to ginger Exclusion Criteria: lack of patient's consent to participate in the study, willingness to cooperate, patients who experience cardiopulmonary arrest during surgery

Intervention Groups: Ginger Group:patients in the ginger group receive two 500 miligeram Vomegan Dineh ginger tablets, each containing 500 mg of ginger, one hour before the surgery. To standardize the appearance of the received medications, they also receive 4 millileter of distilled water in a serum. Ondansetron Group: patients in the ondansetron group receive 8 miligeram of ondansetron. Dexamethasone Group: patients receive 8 miligeram of dexamethasone intravenously before anesthesia induction. Promethazine Group:Patients receive 6.25 miligeram of promethazine intravenously before anesthesia induction.

Nausea, vomiting, sedation

Patients will be allocated into4 groups using a permuted balanced block randomization method with the size of blocks8. Random sequence will be generated by an epidemiologist by running an online program in sealed envelope website (https://www.sealedenvelope.com/). Random chain concealment is done by opaque envelope method

The study is double-blind. The analysis is done by the analyst and outcome evaluator (double-blind) and the participant. The analyst, evaluator, and participant are unaware of the consequences of grouping. The patients under study, as well as all project staff, including surgeons, anesthesia technicians, scrub nurses, and interns, will be unaware of how patients are assigned to the groups.