Effect of Elastic Band Resistance Training on irisin, liver enzymes, Hepatic Steatosis and Metabolic Outcomes in Postmenopausal Women with MASLD

The aim of this study is to investigate the effect of elastic band resistance training on irisin, liver enzymes, hepatic steatosis and metabolic outcomes in obese postmenopausal women with MASLD

Two-arm randomized controlled trial (Elastic band resistance training and control) with pre- and post-intervention assessments.

This study was conducted as a clinical trial involving 54 women aged 55-65 years. Participants were randomly and evenly assigned to two groups: Elastic band resistance training group and the control group. The Elastic band resistance training group underwent 8 weeks of training, with three 60-minute sessions per week. Hepatic Steatosis, ALT, AST, GGT, Insulin, Glucose, Irisin were assessed before and after the intervention. No blinding was applied.

Inclusion Criteria: hepatic steatosis, body mass index between 30 and 35 kg/m², stable body weight (±3%) during the preceding three months, and no engagement in structured exercise training within the previous six months. Exclusion criteria: alcohol consumption, diabetes mellitus, hormone therapy, use of medications known to affect hepatic fat content or insulin sensitivity within the prior six months, and any musculoskeletal, cardiovascular, or neurological condition contraindicating participation in resistance exercise.

Elastic band resistance training group and the control group. Elastic band resistance training group completed a supervised elastic band resistance training program three times per week for eight consecutive weeks, yielding a total of 24 sessions, while the control group did not participate in any physical activity.

Hepatic Steatosis, ALT, AST, GGT, Insulin, Glucose, Irisin

Dear IRCT Team, First, we sincerely appreciate your valuable cooperation and for implementing the requested corrections in the clinical trial record. Upon reviewing the updated record, we noticed that the Body Mass Index (BMI) and age criterion in the Abstract section has not yet been updated. This discrepancy was due to an administrative data entry error during the initial registration and does not reflect any change in the approved protocol, eligibility criteria, or study population. We sincerely apologize for this oversight and kindly request, if possible, that the Abstract section also be updated to ensure full consistency between the registry record, the approved protocol, and the manuscript. Thank you very much for your kind support and cooperation.

In this study, simple randomization was used to assign participants to study groups. The randomization unit was individual, meaning that each person was independently assigned to one of the two groups: elastic band resistance training group (n = 27) or the control group (n = 27). The randomization tool was EXECL software which generated the random sequence before the study began to prevent allocation bias. Allocation concealment was ensured using sealed and numbered opaque envelopes containing the group assignment for each participant. These envelopes were opened only after a participant's eligibility was confirmed by an independent researcher not involved in the randomization process. Stratified randomization was applied based on age to ensure balance across groups for these key variables.

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