Comparison of two types of corticosteroid mouthwashes, Betamethasone and Dexamethasone, in the treatment of patients with aphthous stomatitis and lichen planus

Comparison of Two Corticosteroid Mouthwashes, Betamethasone and Dexamethasone, in the Treatment of Patients with Aphthous Stomatitis and Oral Lichen Planus

In the second intervention group, a combination of 6 vials of dexamethasone ampoules, nystatin drops (100,000 units), aluminum hydroxide syrup (40 mg), and diphenhydramine syrup (160 mg) was prepared. Patients then used the dexamethasone mouthwash three times a day for 2 minutes each time, over a period of 14 days.

This double-blind study will be conducted at the Dental Clinic of the Faculty of Dentistry in Isfahan. In this double-blind study, patients were informed about their participation, while both the researchers and participants were kept blinded to group allocation. To achieve this, identical unlabeled bottles were prepared and assigned to patients using confidential coding. Patients were instructed not to eat or drink for up to 30 minutes after using the mouthwash.

Inclusion criteria:Informed consent; Aged 18 years and older; Clinical and pathological diagnosis of oral aphthous stomatitis or lichen planus; Appropriate general health Exclusion criteria:Receipt of topical or systemic corticosteroids within the past three months; Known hypersensitivity to betamethasone or dexamethasone; Presence of severe or impactful systemic and underlying diseases; History of oral fungal infections pregnancy or breastfeeding

In the first intervention group, a combination of 6 vials of betamethasone ampoules, nystatin drops (100,000 units), aluminum hydroxide syrup (40 mg), and diphenhydramine syrup (160 mg) was prepared. Patients then used the betamethasone mouthwash three times a day for 2 minutes each time, over a period of 14 days.

Allergy and oral thrush; Dry mouth; Pain severity

Randomization using the blocking method with blocks in sizes 6 and 9. For randomization, the site https://www.sealedenvelope.com is used. All codes are recorded on paper and stored in specific envelopes. Each of the generated codes is kept separately inside the envelope and the secretary gives one of these envelopes to the patient before the patient enters the doctor's room. Accordingly, the next patient code is not predictable. The doctor determines which treatments to perform based on the patient's code. Only the physician performing the intervention will be aware of the code assigned to the patient. After evaluating the outcome, based on the patient's name, the collected information will be linked to the assigned code.

In this double-blind study, patients are informed about their participation in the study. Both the researchers and participants were kept blinded to group allocation. To achieve this, identical unlabeled bottles were prepared and given to the patients using confidential coding

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