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Study aim:
The effects of combined Mediterranean, gluten-free, lactose-free and low-FODMAP(fermentable oligosaccharides, disaccharides, monosaccharides and polyols) diets accompanied with supplemental formula, and with the consumption of turmeric on patients with ulcerative colitis.
Design:
This research is a randomized clinical trial on 50 patients.
Settings and conduct:
Anthropometric characteristics are calculated from patients with ulcerative colitis at the beginning and end of the study. Also, at the beginning and end of the study, the quality of life questionnaire(IBDQ-9) and the colitis clinical activity index questionnaire(SCCAIQ) are completed for each patient, and 5 cc of blood is taken after 12 hours of fasting to measure the inflammatory factors.Patients receive the diet for 6 weeks according to the group they belong to.
Participants/Inclusion and exclusion criteria:
Entry:The duration of the disease is less than two years, The disease is active in a mild to moderate stage,Not suffering from other diseases,Not using supplement in the past month, BMI over 18.5 and under 30, Age 18 years and above, No change in the type and dosage of the drug consumed during the past month
non-entry: Recurrence of the disease,The presence of abscesses or abdominal fistulas, A history of ileostomy and colostomy, Pregnancy or breastfeeding in women, Receiving tube or intravenous feeding, Following special diets and vegetarianism during the last 3 months
Intervention groups:
1-intervention group(combined prescription of Mediterranean diets, gluten-free, lactose-free, containing small amounts of fermentable carbohydrates with the Supplementary consumption of 25% of energy from formula and consumption of turmeric for 6 weeks) 2-the control group (usual diet for 6 weeks).
Main outcome variables:
TNF-α,hs-CRP,Total AntiOxidative Capacity,quality of life and relapse of the disease will be assessed.