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Study aim: 1. Evaluation of the therapeutic effect of colchicine plus chloroquine in comparison with chloroquine in patients with COVID-19 In terms of the outcome including mortality, transference to ICU and discharge 2. Evaluation of the therapeutic effect of colchicine plus chloroquine in comparison with chloroquine in patients with COVID-19 In terms of the hospitalization duration 3. Evaluation of the therapeutic effect of colchicine plus chloroquine in comparison with chloroquine in patients with COVID-19 In terms of the cessation of fever Design: clinical trial, blinded, phase III, with control group, 100 patients divided into 2 groups, randomized using random number table. Settings and conduct: This blinded clinical trial will be done in Imam Reza hospital of Ardabil on 100 COVID19 patients divided into 2 groups. the participants will be blinded to their regimen. Participants/Inclusion and exclusion criteria: Inclusion criteria: 1. Pulmonary involvement seen in CT-Scan compatible with COVID19 2. Positive PCR of COVID19 Exclusion criteria: 1. Sensitivity to any medications of regimen 2. Renal failure 3.Heart diseas 4. Pregnancy 5. Reluctance to participate in the study Intervention groups: Individuals of intervention group will receive 1 mg tablet of colchicine daily. The participants of the placebo group will receive a similar tablet without therapeutic effects. Main outcome variables: Hospitalization duration; cessation of fever; outcome including mortality; transference to ICU and discharge
IRCTID: IRCT20200418047126N1
  1. Evaluation of the Efficacy and Safety of Colchicine plus Methylprednisolone Pulse Therapy in Treatment of Covid-19 Patients with ARDS
  2. A randomized clinical trial study, comparison of the therapeutic effects of Ivermectin, Kaletra and Chloroquine with Kaletra and Chloroquine in the treatment of patients with coronavirus 2019 (COVID-19)
  3. Effects of colchicine on persistent dyspnea and pulmonary fibrosis of COVID-19 patients after hospital discharge
  4. Comparison of the Effectiveness of Tenofovir antiviral drug beside (Kaletra and Chloroquine) with routine drug regime (Kaletra and Chloroquine) in COVID-19 patients
  5. Evaluation of the effectiveness of Colchicine tablets in mortality and duration of ICU hospitalization in patients under mechanical ventilation diagnosed with COVID-19
  6. evaluation of the effects of the 2-drug diet (hydroxychloroquine + umifenovir(Arbidol)) compared with Hydroxy chlorquine on the of mortality rate in patients with moderate symptoms of COVID-19 infections: A randomized interventional study in Imam Reza Hospital, Mashhad.
  7. Comparison of the effectiveness of Sovodak (sofosbuvir + Daklatasvir) and Keltra treatment regimens in patients with COVID-19: a randomized single-blind study
  8. Evaluation of the efficacy and safety of Adalimumab and methylprednisolone pulse therapy in treatment of Covid-19 patients with ARDS
  9. Efficacy and safety of colchicine on clinical improvement in patients with COVID-19: A randomized, double blind clinical trial
  10. Evaluation of the efficacy and safety of methylprednisolone pulse therapy in treatment of Covid-19 patients with ARDS
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