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Study aim:
Determining the effect of oral honey consumption on postoperative complications and quality of recovery in patients undergoing laparoscopic cholecystectomy
Design:
Clinical trial with control group, parallel groups, double-blind, randomized on 68 patients, we will use random sequencing software to randomize
Settings and conduct:
The study population includes all patients who are candidates for laparoscopic cholecystectomy and are eligible to study who have referred to hospitals in the west of Mazandaran province in 1400-1401. The study is double-blind. The prescribing physician, assistant and patient will not know any of the contents of the drugs and the drug code will be written on the file.
Participants/Inclusion and exclusion criteria:
Inclusion criteria: Laparoscopic cholecystectomy
Age between 18 and 65 years
To be fasting
Having a BMI (body mass index) between 18 and 30
Exclusion criteria:
Having nausea and indigestion
Drug addiction
Being pregnant while studying
Having a history of allergies to honey compounds
Changes in surgical procedures
Intervention groups:
Intervention group: Honey syrup will be produced by NIAK Pharmaceutical Company with the permission of the Food and Drug Administration of the Ministry of Health and Medical Education. This syrup contains compounds of honey, cinnamon, ginger, saffron, cardamom, kholnjan, mastaki, jozboa and basbaseh. Control group: Placebo syrup is also prepared in Niak Pharmaceutical Company, which is packaged in bottles completely similar to honey. The placebo will contain water, acesulfame, sunset yellow and carboxymethylcellulose. Honey will be administered twice in the intervention group and placebo in the control group twice a day, twice before the operation (eight and two hours before the operation) with An anesthesiologist (15 ml) will be consulted
Main outcome variables:
nausea and vomiting, pain, bloating ،quality of recovery.