Study aim: Determining the synergistic role of cognitive behavioral therapy and treatment of the dorsolateral prefrontal cortex on reducing the basic and induced craving for amphetamine and clinical symptoms(anxiety and depression)and improving neuropsychological functions(cognitive inhibition)and behavioral) of amphetamine abusers. Design: A clinical trial with three test groups and one control group, matched, single-blind, randomized, phase 2 on 40 patients. PASS software was used to estimate the sample size. Settings and conduct: The statistical population of this research includes patients with clinical symptoms of substance abuse disorder who were referred to addiction treatment clinics in Mashhad,in the year 2023.Then at least 40 people who have the criteria to enter the research will be randomly replaced in4 groups(three experimental groups and one control group).In this research, a blind intervention study method will be used. Participants/Inclusion and exclusion criteria: Inter:the main diagnosis of(amphetamine)abuse, the consent of the subjects to participate in the research,the absence of neurological diseases-Exit: Having a history of committing suicide and thoughts,having an injury in the head and neck area Intervention groups: Before the intervention,a pre-test will be done in4 experimental groups by implementing questionnaires.Then group1:recipient of cognitive-behavioral therapy.Group2:recipient of stimulation therapy with direct current from the skull of the dorsolateral frontal region.Group3 both They will receive the treatment to check synergy.The control group will not receive any other intervention other than cognitive behavioral therapy.After the intervention,a post-test will be carried out from all4groups by implementing questionnaires. Main outcome variables: Craving for basic and induced use of amphetamine, clinical signs, neuropsychological functions.