Study aim: Determining the effect of yoga intervention on general health and mindfulness of female nursing students at Shiraz University of Medical Sciences Design: This study is a randomized controlled clinical trial using a blocked randomization method with G*Power software, with a control group, parallel groups, and no blinding, conducted on 144 female nursing students. Settings and conduct: This study is a randomized clinical trial conducted on female nursing students in semesters 4 to 8 of the Faculty of Nursing and Midwifery, Shiraz University of Medical Sciences. Participants are randomly assigned. The intervention group will receive virtual yoga training for 8 weeks, while the control group will not receive any intervention. Blinding was not performed in the study. Participants/Inclusion and exclusion criteria: Participants in this study include female undergraduate nursing students who are in their fourth to eighth semesters, have at least two semesters of experience in clinical settings, are willing to participate in the study, and have access to a smartphone and the Internet to receive educational videos, communicate with the researcher, and send daily practice reports. Intervention groups: In the intervention group, eight offline educational sessions (one session per week using videos) will be provided over eight consecutive weeks. The participants will perform daily physical exercises, breathing exercises, relaxation, and meditation at home or in the student dormitory. Before the sessions begin, an in-person orientation session will be held to explain the intervention.Then, the yoga sessions will be conducted virtually under the supervision of the researchers in eight sessions over eight consecutive weeks (one one-hour session per week). No intervention will be provided to the control group. Main outcome variables: mindfulness and general health.