Comparison of two different doses of thiopental sodium in elective cesarean section (C/S) under general anesthesia on depth of anesthesia with Isolated Forearm Technique (IFT) and on neonatal neurobehavioral test

Objective: Comparison of two different doses of thiopental sodium in elective cesarean section (C/S) under general anesthesia on depth of anesthesia with Isolated Forearm Technique (IFT) and on neonatal neurobehavioral test Inclusion criteria: pregnant women (ASA I- II) who are under general anesthesia for elective cesarean section. Exclusion criteria: Patients who are not properly cooperate; prior use of sulfate MgSO4; mental disorders; a history of previous awareness during general anesthesia, taking blood pressure medication or vasodilators or vasodepressor and human stimulant or psychotropic drugs; neuromuscular diseases, opium addicts; detection of any fetal abnormalities by ultrasonography. Intervention: 70 patients divided into two groups one or two: Anesthesia will induce by Thiopental (5mg / kg) in group one and Thiopental (7 mg / kg) in group two and Scholin (2 mg / kg) , maintenance was with 50% N2O, O2, Sevoflurane and after birth by N2O 50%, O2, sevoflurane blood pressure cuff will fasten on the patients’ arm and inflated (200 mmHg) immediately before administering the drugs. After induction, a recorded message will be played once by the headphones every 30 seconds to move the fingers of the dominant hand. Hand movement will be scored as follows after playing message: No movement: zero /uncertain movements: open and close the fingers: 2 before induction of anesthesia, BIS sensor device will be installed according to the manufacturer's instructions on the forehead of the patient. BIS values and IFT following events will be recorded at baseline, Induction of anesthesia, laryngoscopy and intubation, Skin incision, opening the peritoneum, Uterine incision, uterine retraction, childbirth, Uterine closure, tying the layers under the skin, Subcutaneous closures, at the start of skin closure,2 minutes after skin closure, eye opening and extubation. The neonate Apgar score is measured at 0, 5, and 20 minutes after birth and neurobehavioral test evaluates after the birth of the newborn.

Vice Chancellor for Research, Shiraz University of Medical Sciences