Effects of concurrent Omega-3 and Cranberry juice consumption on eradication of Helicobacter pylori, gastrointestinal symptoms, some serum inflammatory and oxidative stress markers in adults with Helicobacter pylori infection

Evaluation of the effects of concurrent Omega-3 and Cranberry juice consumption on eradication of Helicobacter pylori, gastrointestinal symptoms, some serum inflammatory and oxidative stress markers in adults with Helicobacter pylori infection

Among patients referred to the liver and gastroenterologist, 92 patients with gastrointestinal complaints and inclusion criteria will be included in the study. Then, individuals will be allocated into one of the three intervention groups or the control group using a randomized blocked division (4 block based on BMI and gender).

The present study will be performed on adults referred to the liver and gastroenterologist of Soroush Clinic in Ahvaz in 1396.

Inclusion criteria: Having age between18 to 65 years old, infection with Helicobacter pylori, gastrointestinal complaints and body mass index of 18.5 to 35 kg / h. Exclusion criteria: Having a history of drug therapy to eradicate Helicobacter pylori infection, stomach surgery, history of peptic ulcer and gastrointestinal malignancies, having any disease that causes inflammation and increases levels of inflammatory markers, such as diabetes, cardiovascular disease, respiratory infections such as asthma. .., having immunodeficiency diseases, having chronic diseases requiring drug treatment, taking medications other than prescription drugs during the study, taking antibiotics or proton pump inhibitors or H2 blockers over the past 2 months, taking omega-3 supplementation at least 3 months before starting the study, using of any dietary supplement at least 3 months before starting the study, changes in the diet during the study period and the consumption of less than 80% of the supplements delivered to the patient during the study period.

Interventional group 1: Two weeks taking of three treatments of Helicobacter pylori including: Pentoprazole 40 mg twice daily, Amoxicillin 1 g twice daily, Bismuth 2 mg 4 times daily, Clarithromycin 500 mg twice daily for two weeks+ Cranberry juice (400 ml) enriched with omega-3 (2 g) for 4 weeks. Intervention group 2: Two weeks taking of three treatments of Helicobacter pylori including: Pentoprazole 40 mg twice daily, Amoxicillin 1 g twice daily, Bismuth 2 mg 4 times daily, Clarithromycin 500 mg twice daily + Cranberry juice (400 ml) for 4 weeks Intervention group 3:Two weeks taking of three treatments of Helicobacter pylori including: Pentoprazole 40 mg twice daily, Amoxicillin 1 g twice daily, Bismuth 2 mg 4 times daily, Clarithromycin 500 mg twice daily for two weeks+ Omega- 3 (two grams) for 4 weeks Control group: Two weeks taking of three treatments of Helicobacter pylori including: Pantoprazole 40 mg twice daily, amoxicillin 1 g twice daily, bismuth 2 mg 4 times daily, and clarithromycin 500 mg twice daily for two weeks.

Primary outcome variable: Negative anti-Helicobacter pylori antigen; Determination and comparison of Helicobacter pylori caused gastrointestinal complaints questionnaire scale; serum levels of interleukin-17, TGFβ1 and INF-γ ; Serum levels of TAC and MDA

By using randomized blocked categorization (4 block based on BMI and sex), individuals will be placed in one of the three intervention groups or in the control group.