History
# Registration date Revision Id
3 2022-09-14, 1401/06/23 243563
2 2022-01-12, 1400/10/22 214428
1 2020-03-22, 1399/01/03 126218
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  • Protocol summary

    Study of the effect of oats supplementation with exercise on anthropometric status, some metabolic and inflammatory profiles of women with polycystic ovary syndrome
    Evaluation of the effect of exercise training on anthropometric status, some metabolic, inflammatory and oxidative stress profiles of women with polycystic ovary syndrome.
    بررسی تاثیر مصرف مکمل یولاف همراه با فعالیت ورزشی، بر وضعیت آنتروپومتریک، برخی پروفایل متابولیک و التهابی زنان مبتلا به سندرم تخمدان پلی کیستیک
    بررسی تاثیر فعالیت ورزشی، بر وضعیت آنتروپومتریک، برخی پروفایل متابولیک و التهابی زنان مبتلا به سندرم تخمدان پلی کیستیک.
    This study is a double-blind clinical trial. The study population will be all women with polycystic ovary syndrome referred to Imam Reza hospital of Kermanshah. 90 eligible patients will be selected conveniently and randomly assigned to 6 intervention and control groups (5 intervention groups and one control group).
    This study is an open-label clinical trial. The study population will be all women with polycystic ovary syndrome referred to Imam Reza hospital of Kermanshah. 90 eligible patients will be selected conveniently and randomly assigned to 3 intervention and control groups (2 intervention groups and one control group).
    این مطالعه یک کارازمایی بالینی دو سو کور است. جامعه پژوهش شامل کلیه زنان مبتلا به سندرم تخمدان پلی کیستیک مراجعه کننده به بیمارستان امام رضا شهر کرمانشاه خواهد بود. تعداد 90نفر از بیماران واجد شرایط به شیوه در دسترس انتخاب خواهند شد و به صورت تصادفی در 6 گروه مداخله و کنترل (5 گروه مداخله و یک گروه کنترل )گمارده می شوند
    این مطالعه یک کارازمایی بالینی بدون کورسازی است. جامعه پژوهش شامل کلیه زنان مبتلا به سندرم تخمدان پلی کیستیک مراجعه کننده به بیمارستان امام رضا شهر کرمانشاه خواهد بود. تعداد 90نفر از بیماران واجد شرایط به شیوه در دسترس انتخاب خواهند شد و به صورت تصادفی در 3 گروه مداخله و کنترل (2 گروه مداخله و یک گروه کنترل ) گمارده می شوند.
    The first intervention group will receive 40 grams of oat supplement (manufactured by Bakhshajin Agro-industry) daily. The second intervention group will receive 65 to 70 percent Vo2max aerobic training three times a week for 8 weeks with a treadmill. The third intervention group will receive 40 grams of oat supplement and 65 to 70 percent Vo2max aerobic training three times a week for 8 weeks with a treadmill. The fourth intervention group will receive 50% 1RM resistance training twice a week for 8 weeks. The fifth intervention group will receive 40 grams of oat supplement with resistance training at 50% 1RM twice a week for 8 weeks. The control group will receive no intervention.
    The first intervention group will receive alternative training with 50 to 110 percent maximum aerobic velocity (MAV) three times a week for 8 weeks with a treadmill. The second intervention group will receive combination of aerobic and resistance training with 50% to 70% 1RM and 50% to 70% maximum heartbeat rate (MHR) three times a week for 8 weeks. The control group will receive no intervention.
    گروه مداخله اول روزانه 40 گرم مکمل یولاف (شرکت کشت و صنعت بخشاژین) دریافت خواهند. گروه مداخله دوم تمرین هوازی با شدت 65 تا 70 درصد Vo2max به کمک تردمیل سه بار در هفته به مدت 8 هفته دریافت خواهند کرد. گروه مداخله سوم روزانه 40 گرم مکمل یولاف و تمرین هوازی با شدت 65 تا 70 درصد Vo2max به کمک تردمیل سه بار در هفته به مدت 8 هفته دریافت خواهند کرد. گروه مداخله چهارم تمرینات مقاومتی با شدت %50 1RM دوبار در هفته به مدت 8 هفته دریافت خواهند کرد. گروه مداخله پنجم روزانه 40 گرم مکمل یولاف با تمرینات مقاومتی با شدت %50 1RM دوبار در هفته به مدت 8 هفته دریافت خواهند کرد. گروه کنترل هیچ مداخله ای دریافت نخواهند کرد.
    گروه مداخله اول تمرین تناوبی با شدت 50 تا 110 درصد حداکثر سرعت هوازی MAV بر روی تردمیل سه بار در هفته به مدت 8 هفته دریافت خواهند کرد. گروه مداخله دوم تمرینات ترکیبی مقاومتی و هوازی با شدت % تا 70%50 1RM و 50 تا 70 درصد ضربان قلب بیشینه MHR سه بار در هفته به مدت 8 هفته دریافت خواهند کرد. گروه کنترل هیچ مداخله ای دریافت نخواهند کرد.
    Lipid profile; Total Testosterone; HS-CRP Inflammatory Protein; Blood sugar; Body Mass Index
    Lipid profile; Fasting blood Glucose; Insulin; Insulin resistance (HOMA-IR), Maximum oxygen consumption (V̇O₂ max)
    پروفایل چربی؛ تستسترون کل؛ پروتئین التهابی حساس به هورمون HS-CRP قند خون؛ شاخص توده بدنی
    مقاومت به انسولین (HOMA-IR)، حداکثر میزان مصرف اکسیژن (VO2max)
  • General information

    Double blinded
    Not blinded
    1
    1
    2-3
    3
    empty
    Change in proposal
    empty
    تغییر در پروپزال
    Study of the effect of oats supplementation with exercise on anthropometric status, some metabolic and inflammatory profiles of women with polycystic ovary syndrome
    Evaluation of the effect of exercise on women with polycystic ovary syndrome status.
    بررسی تاثیر مصرف مکمل یولاف همراه با فعالیت ورزشی، بر وضعیت آنتروپومتریک، برخی پروفایل متابولیک و التهابی زنان مبتلا به سندرم تخمدان پلی کیستیک
    بررسی تاثیر فعالیت ورزشی، بر وضعیت زنان مبتلا به سندرم تخمدان پلی کیستیک.
    Study of the effect of oats supplementation with exercise on anthropometric status, some metabolic and inflammatory profiles of women with polycystic ovary syndrome
    Evaluation of the effect of exercise on anthropometric status, some metabolic and inflammatory profiles of women with polycystic ovary syndrome.
    بررسی تاثیر مصرف مکمل یولاف همراه با فعالیت ورزشی، بر وضعیت آنتروپومتریک، برخی پروفایل متابولیک و التهابی زنان مبتلا به سندرم تخمدان پلی کیستیک
    بررسی تاثیر فعالیت ورزشی، بر وضعیت آنتروپومتریک، برخی پروفایل متابولیک و التهابی زنان مبتلا به سندرم تخمدان پلی کیستیک.
    Using the random number table. That is, the first 15 numbers that randomly are selected in the first stage will be assigned to the first group.15 numbers that randomly are selected in the second stage will be assigned to the second group, 15 numbers that randomly are selected in the third stage will be assigned to the third group,15 numbers that randomly are selected in the fourth stage will be assigned to the fourth group and 15 numbers that randomly are selected in the fifth stage will be assigned to the fifth group
    Using the random number table. It means the first 30 numbers that randomly are selected in the first stage will be assigned to the first group. 30 numbers that randomly are selected in the second stage will be assigned to the second group, and 30 numbers that randomly are selected in the third stage will be assigned to the third group.
    با استفاده از جدول اعداد تصادفی. به این صورت که ۱۵ عددی که در مرحله اول به صورت تصادفی انتخاب می شود به گروه اول اختصاص داده می شود. ۱۵ عددی که در مرحله دوم به صورت تصادفی انتخاب می شود به گروه دوم، ۱۵ عددی که در مرحله سوم به صورت تصادفی انتخاب می شود به گروه سوم، ۱۵ عددی که در مرحله چهارم به صورت تصادفی انتخاب می شود به گروه چهارم و ۱۵ عددی که در مرحله پنجم به صورت تصادفی انتخاب می شود به گروه پنجم اختصاص داده می شود.
    با استفاده از جدول اعداد تصادفی. به این صورت که 30 عددی که در مرحله اول به صورت تصادفی انتخاب می شود به گروه اول اختصاص داده می شود. 30 عددی که در مرحله دوم به صورت تصادفی انتخاب می شود به گروه دوم، 30 عددی که در مرحله سوم به صورت تصادفی انتخاب می شود به گروه سوم، اختصاص داده می شود.
    In this study, researchers and data analysts were kept blind to the allocation of study groups.
    در این مطالعه محقق و آنالیز کننده داده نسبت به تخصیص گروه های مطالعه کور نگه داشته شده اند.
  • Primary outcomes

    #1
    Lipid profile
    Insulin resistance
    پروفایل چربی
    مقاومت به انسولین
    blood test
    Standard formula
    آزمایش خون
    فرمول استاندارد
    #2
    Total Testosterone
    Maximum oxygen consumption (V̇O₂ max)
    توتال تستسترون
    حداکثر میزان مصرف اکسیژن (V̇O₂ max )
    Using Kate Roth
    Standard formula
    با استفاده از کیت Roth
    فرمول استاندارد
    #3
    Inflammatory protein hormone-sensitive HS-CRP
    empty
    پروتئین التهابی حساس به هورمون HS-CRP
    empty
    Beginning and end of the study (after 8 weeks)
    empty
    ابتدای مطالعه و پایان مطالعه (بعد از 8 هفته)
    empty
    Using Kate dbc
    empty
    با استفاده از کیت dbc
    empty
    #4
    Blood sugar
    empty
    قند خون
    empty
    Beginning and end of study (after 8 weeks)
    empty
    ابتدای مطالعه و پایان مطالعه (بعد از 8 هفته)
    empty
    blood test
    empty
    آزمایش خون
    empty
    #5
    Body Mass Index
    empty
    شاخص توده بدنی
    empty
    Beginning and end of the study (after 8 weeks)
    empty
    ابتدای مطالعه و پایان مطالعه (بعد از 8 هفته)
    empty
    Using digital scales and centimeters
    empty
    با استفاده از ترازو دیجیتالی و سانتی متر
    empty
  • Intervention groups

    #1
    The first intervention group will receive 40 grams of oat supplement (manufactured by Bakhshajin Agro-industry) daily
    The first intervention group, will receive alternative training with 50 to 110 percent maximum aerobic velocity (MAV) three times a week for 8 weeks with a treadmill.
    گروه مداخله اول روزانه 40 گرم مکمل یولاف (شرکت کشت و صنعت بخشاژین) دریافت خواهند.
    گروه مداخله اول، تمرین تناوبی با شدت 50 تا 110 درصد حداکثر سرعت هوازی MAV بر روی تردمیل سه بار در هفته به مدت 8 هفته دریافت خواهند کرد.
    #2
    The second intervention group will receive 65 to 70 percent Vo2max aerobic training three times a week for 8 weeks with a treadmill
    The second intervention group will receive a combination of aerobic and resistance training with 50% to 70% 1RM and 50% to 70% maximum heartbeat rate (MHR) three times a week for 8 weeks.
    گروه مداخله دوم تمرین هوازی با شدت 65 تا 70 درصد Vo2max به کمک تردمیل سه بار در هفته به مدت 8 هفته دریافت خواهند کرد.
    گروه مداخله دوم، تمرینات ترکیبی مقاومتی و هوازی با شدت % تا 70%50 1RM و 50 تا 70 درصد ضربان قلب بیشینه MHR سه بار در هفته به مدت 8 هفته دریافت خواهند کرد.
    #3
    The third intervention group will receive 40 grams of oat supplement and 65 to 70 percent Vo2max aerobic training three times a week for 8 weeks with a treadmill.
    The fifth intervention group will receive 40 grams of oat supplement of with resistance training at 50% 1RM twice a week for 8 weeks
    گروه مداخله سوم روزانه 40 گرم مکمل یولاف و تمرین هوازی با شدت 65 تا 70 درصد Vo2max به کمک تردمیل سه بار در هفته به مدت 8 هفته دریافت خواهند کرد.
    گروه مداخله پنجم روزانه 40 گرم مکمل یولاف با تمرینات مقاومتی با شدت %50 1RM دوبار در هفته به مدت 8 هفته دریافت خواهند کرد.
    #4
    Treatment - Other
    Other
    The fourth intervention group will receive 50% 1RM resistance training twice a week for 8 weeks.
    The control group will receive no intervention
    گروه مداخله چهارم تمرینات مقاومتی با شدت %50 1RM دوبار در هفته به مدت 8 هفته دریافت خواهند کرد.
    گروه کنترل هیچ مداخله ای دریافت نخواهند کرد.
    #5
    Treatment - Other
    empty
    The fifth intervention group will receive 40 grams of oat supplement of with resistance training at 50% 1RM twice a week for 8 weeks
    empty
    گروه مداخله پنجم روزانه 40 گرم مکمل یولاف با تمرینات مقاومتی با شدت %50 1RM دوبار در هفته به مدت 8 هفته دریافت خواهند کرد.
    empty
    #6
    Other
    empty
    The control group will receive no intervention
    empty
    گروه کنترل هیچ مداخله ای دریافت نخواهند کرد.
    empty

Protocol summary

Study aim
Evaluation of the effect of exercise training on anthropometric status, some metabolic, inflammatory and oxidative stress profiles of women with polycystic ovary syndrome.
Design
This study is an open-label clinical trial. The study population will be all women with polycystic ovary syndrome referred to Imam Reza hospital of Kermanshah. 90 eligible patients will be selected conveniently and randomly assigned to 3 intervention and control groups (2 intervention groups and one control group).
Settings and conduct
This study that will be conducted in Imam Reza hospital of Kermanshah is a double-blind one that , researchers and data analysts were kept blind to the allocation of study groups
Participants/Inclusion and exclusion criteria
Inclusion criteria: Patients with polycystic ovary syndrome; Age between 18 to 40 years Exclusion criteria: Taking oral contraceptives; Taking hormone drugs affecting total testosterone levels over the past three months
Intervention groups
The first intervention group will receive alternative training with 50 to 110 percent maximum aerobic velocity (MAV) three times a week for 8 weeks with a treadmill. The second intervention group will receive combination of aerobic and resistance training with 50% to 70% 1RM and 50% to 70% maximum heartbeat rate (MHR) three times a week for 8 weeks. The control group will receive no intervention.
Main outcome variables
Lipid profile; Fasting blood Glucose; Insulin; Insulin resistance (HOMA-IR), Maximum oxygen consumption (V̇O₂ max)

General information

Reason for update
Change in proposal
Acronym
IRCT registration information
IRCT registration number: IRCT20130812014333N143
Registration date: 2020-03-22, 1399/01/03
Registration timing: prospective

Last update: 2022-01-27, 1400/11/07
Update count: 2
Registration date
2020-03-22, 1399/01/03
Registrant information
Name
Feizollah Foroughi
Name of organization / entity
kermanshah University of Medical Sciences
Country
Iran (Islamic Republic of)
Phone
+98 83 1821 4653
Email address
fforoughi@kums.ac.ir
Recruitment status
Recruitment complete
Funding source
Expected recruitment start date
2020-04-02, 1399/01/14
Expected recruitment end date
2020-10-05, 1399/07/14
Actual recruitment start date
empty
Actual recruitment end date
empty
Trial completion date
empty
Scientific title
Evaluation of the effect of exercise on anthropometric status, some metabolic and inflammatory profiles of women with polycystic ovary syndrome.
Public title
Evaluation of the effect of exercise on women with polycystic ovary syndrome status.
Purpose
Treatment
Inclusion/Exclusion criteria
Inclusion criteria:
Patients with polycystic ovary syndrome Age between 18 to 40 years
Exclusion criteria:
Taking oral contraceptives Taking hormone drugs affecting total testosterone levels over the past three months
Age
From 18 years old to 40 years old
Gender
Female
Phase
3
Groups that have been masked
No information
Sample size
Target sample size: 90
Randomization (investigator's opinion)
Randomized
Randomization description
Using the random number table. It means the first 30 numbers that randomly are selected in the first stage will be assigned to the first group. 30 numbers that randomly are selected in the second stage will be assigned to the second group, and 30 numbers that randomly are selected in the third stage will be assigned to the third group.
Blinding (investigator's opinion)
Not blinded
Blinding description
Placebo
Not used
Assignment
Other
Other design features

Secondary Ids

empty

Ethics committees

1

Ethics committee
Name of ethics committee
Ethics committee of Kermanshah University of Medical Sciences
Street address
Building No.2, Shahid Beheshti, Vice Chancellor for Research Affairs, Kermanshah University of Medical Sciences
City
Kermanshah
Province
Kermanshah
Postal code
6715847141
Approval date
2020-02-03, 1398/11/14
Ethics committee reference number
ir.kums.rec.1398.1186

Health conditions studied

1

Description of health condition studied
Polycystic ovary syndrome
ICD-10 code
E28.2
ICD-10 code description
Polycystic ovarian syndrome

Primary outcomes

1

Description
Insulin resistance
Timepoint
Beginning and end of the study (after 8 weeks)
Method of measurement
Standard formula

2

Description
Maximum oxygen consumption (V̇O₂ max)
Timepoint
Beginning and end of the study (after 8 weeks)
Method of measurement
Standard formula

Secondary outcomes

empty

Intervention groups

1

Description
The first intervention group, will receive alternative training with 50 to 110 percent maximum aerobic velocity (MAV) three times a week for 8 weeks with a treadmill.
Category
Treatment - Other

2

Description
The second intervention group will receive a combination of aerobic and resistance training with 50% to 70% 1RM and 50% to 70% maximum heartbeat rate (MHR) three times a week for 8 weeks.
Category
Treatment - Other

3

Description
The fifth intervention group will receive 40 grams of oat supplement of with resistance training at 50% 1RM twice a week for 8 weeks
Category
Treatment - Other

4

Description
The control group will receive no intervention
Category
Other

Recruitment centers

1

Recruitment center
Name of recruitment center
Emam Reza Hospital
Full name of responsible person
Dr. Solmaz Alavi Milani
Street address
Emam Reza Hospital, Parastar Boulevard
City
Kermanshah
Province
Kermanshah
Postal code
6715847141
Phone
+98 83 3427 6306
Email
s.alavimilani@yahoo.com

Sponsors / Funding sources

1

Sponsor
Name of organization / entity
Kermanshah University of Medical Sciences
Full name of responsible person
Dr. Farid Najafi
Street address
Building No.2, Shahid Beheshti, Vice Chancellor for Research Affairs, Kermanshah University of Medical Sciences
City
Kermanshah
Province
Kermanshah
Postal code
6715847141
Phone
+98 83 3836 0014
Email
fnajafi@kums.ac.ir
Grant name
Grant code / Reference number
Is the source of funding the same sponsor organization/entity?
Yes
Title of funding source
Kermanshah University of Medical Sciences
Proportion provided by this source
100
Public or private sector
Public
Domestic or foreign origin
Domestic
Category of foreign source of funding
empty
Country of origin
Type of organization providing the funding
Academic

Person responsible for general inquiries

Contact
Name of organization / entity
Kermanshah University of Medical Sciences
Full name of responsible person
Dr. Solmaz Alavi Milani
Position
Member of Kermanshah University of Medical Sciences
Latest degree
Specialist
Other areas of specialty/work
Gynecology and Obstetrics
Street address
Emam Reza Hospital, Parastar Boulevard
City
Kermanshah
Province
Kermanshah
Postal code
6715847141
Phone
+98 83 3427 6306
Email
s.alavimilani@yahoo.com

Person responsible for scientific inquiries

Contact
Name of organization / entity
Kermanshah University of Medical Sciences
Full name of responsible person
Dr. Solmaz Alavi Milani
Position
Member of Kermanshah University of Medical Sciences
Latest degree
Specialist
Other areas of specialty/work
Gynecology and Obstetrics
Street address
Emam Reza Hospital, Parastar Boulevard
City
Kermanshah
Province
Kermanshah
Postal code
6715847141
Phone
+98 83 3427 6306
Email
s.alavimilani@yahoo.com

Person responsible for updating data

Contact
Name of organization / entity
Kermanshah University of Medical Sciences
Full name of responsible person
Dr. Solmaz Alavi Milani
Position
Member of Kermanshah University of Medical Sciences
Latest degree
Specialist
Other areas of specialty/work
Gynecology and Obstetrics
Street address
Emam Reza Hospital, Parastar Boulevard
City
Kermanshah
Province
Kermanshah
Postal code
6715847141
Phone
+98 83 3427 6306
Email
s.alavimilani@yahoo.com

Sharing plan

Deidentified Individual Participant Data Set (IPD)
Yes - There is a plan to make this available
Study Protocol
Undecided - It is not yet known if there will be a plan to make this available
Statistical Analysis Plan
Undecided - It is not yet known if there will be a plan to make this available
Informed Consent Form
Yes - There is a plan to make this available
Clinical Study Report
Yes - There is a plan to make this available
Analytic Code
Not applicable
Data Dictionary
Not applicable
Title and more details about the data/document
The main outcomes of the study will be shared.
When the data will become available and for how long
6 months
To whom data/document is available
If requested, results will be made available to other academic researchers
Under which criteria data/document could be used
Collected data is confidential and will not be shared with anyone else
From where data/document is obtainable
Send E-mail to the responsible for the update to get the documentation
What processes are involved for a request to access data/document
Documentation will be emailed within a 15-day timeframe
Comments
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